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Richard I. Fisher, MD

Richard Fisher, MD

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111

President and CEO

Cancer Center Director

Senior Associate Dean, Lewis Katz School of Medicine, Temple University

Robert C. Young, MD, Chair in Cancer Research

Specialties

Research Program

Key Awards

  • Chair, NCI Specialized Programs of Research Excellence (SPORE) review committee, 2010
  • Member, National Cancer Institute (NCI) lymphoma steering committee from 2009-present
  • Member, Board of Scientific Advisors for the V Foundation from 2003-present

President, CEO  and Cancer Center Director

As President and CEO, Dr. Fisher is responsible for overseeing and leading the Fox Chase Cancer Center.  He is also senior associate dean for cancer programs at the Lewis Katz School of Medicine at Temple University.

At the Fox Chase Cancer Center, Richard I. Fisher, MD, is the President, Chief Executive Officer, and Cancer Center Director, where he leads all aspects of the center. As part of the Temple University Health System, he is also senior associate dean for cancer programs.

Fisher majored in chemistry and physics at Harvard University before earning his medical degree, cum laude, from Harvard Medical School in 1970. From 1970-1972, he was an intern and resident at Massachusetts General Hospital. Highlights of his career include: immunology and oncology fellowships at the National Cancer Institute, Bethesda, MD, from 1972-1975; director of the Cardinal Bernadin Cancer Center at Loyola University Stritch School of Medicine from 1984-2001; director of the Hematology/Oncology Division at the University of Rochester School of Medicine and Dentistry (URSMD) from 2001-2009; and senior associate dean for clinical affairs and director of the Rochester Medical Faculty Group at URSMD from 2008-2011. He also served as principal investigator for a Lymphoma SPORE (Specialized Program of Research Excellence) grant.

Fisher has also held a number of important leadership positions in the oncology community including: Chair of the lymphoma committee of the Southwest Oncology Group (SWOG) from 1984-2014; deputy group chair of SWOG from 2005-2013; and Chair of the Lymphoma Research Foundation Scientific Advisory Board from 2008-2010. Other roles, honors, and awards include: Member of the Board of Scientific Advisors for the V Foundation from 2003-present; Member of the National Cancer Institute (NCI) lymphoma steering committee from 2009-2014; and Chair of the NCI Specialized Programs of Research Excellence (SPORE) review committee in 2012.

Educational Background

  • Oncology Fellow, Medicine Branch National Cancer Institute, Bethesda, MD, 1975
  • Assistant Resident, Medicine, Massachusetts General Hospital, Boston, MA, 1972
  • MD, Harvard Medical School-graduate Cum Laude, 1970

Certifications

  • Diplomate, American Board of Internal Medicine
  • Diplomate, American Board of Internal Medicine, Subspecialty of Oncology
  • Diplomate, National Board of Medical Examiners

Memberships

  • American Association for Cancer Research
  • American College of Physician Executives
  • American Medical Association
  • American Society of Clinical Oncology
  • American Society of Hematology
  • American Association of Immunologists
  • American College of Physicians
  • Association of Subspecialty Professors
  • Central Society for Clinical Research
  • Clinical Immunology Society
  • Chicago Medical Society
  • Chicago Society of Internal Medicine
  • European Society for Medical Oncology
  • Illinois State Medical Society

Honors & Awards

  • Best Doctors in America®, Best Doctors Inc., 2014
  • The Best Doctors in America: Castle Connolly Medical Publications 1999-Present
  • Distinction and HOPE Award, American Cancer Society, 2010
  • Team Science Award, Cytebrine Working Group, 2010
  • Harold Amos Fellow, Harvard Medical School Dean’s Council, 2010
  • Freundlich Leadership Award, Lymphoma Research Foundation, 2009
  • Davey Memorial Award for Outstanding Cancer Research, University of  Rochester Medical Center, 2006
  • Grinberg/Wisch Endowed Visiting Lectureship in Hematology/Oncology, Mount Sinai School of Medicine, 2005
  • Derrick Crowther Lecturer, Cologne, Germany, 2001
  • Member, Lymphoma Research Foundation of America's Honorary Medical Board, 2000-2001

Research Program

Research Interests

  • Development of novel treatments for non-Hodgkin’s lymphoma and Hodgkin disease
  • Development of prognostic markers for non-Hodgkin’s lymphoma and Hodgkin disease
  • Understanding the immunologic response to non-Hodgkin’s lymphoma and Hodgkin disease

Selected Publications

Ngo, V.N., Young, R.M., Schmitz, R., Jhavar, S., Xiao, W., Kohlhammer, H., Xu, W.,Yang, Y., Zhao, H., Shaffer, A.L., Romesser, P., Wright, G., Powell, J., Rosenwald, A., Muller-Hermelink, H.K., Ott, G., Gascoyne, R.D., Connors, J.M., Rimsza, L.M., Campo, E., Jaffe, E.S., Delabie, J., Smeland, E.B., Fisher, R.I., Braziel, R.M., Tubbs, R.R., Cook, J.R., Weisenburger, D.D., Chan, W.C., and Staudt, L.M. Oncogenically Active MYDSS Mutations in Human Lymphoma. Nature. 470:115-119, 2011.   PubMed

 Davis, R.E; Ngo, V.N; Lenz, G; Tolar, P.; Young, R.; Romesser, P.B.; Kohlhammer, H.; Lamy, L; Zhao, H.; Yang, Y.; Xu, W.; Shaffer, A.L.; Wright, G.; Xiao, W.; Powell, J.; Jiang, J.; Thomas, C.J.; Rosenwald, A.; Ott, G.; Muller-Hermelink, H.K.; Gascoyne, R.D.; Connors, J.M.; Rimsza, L.M.; Campo, E.; Jaffe, E.S.; Delabie, J.; Smeland, E.B.; Fisher, R.I.; Braziel, R.M.; Tubbs, R.R.; Cook, J.R.; Weisenburger, D.D.; Chan, W.C.; Pierce, S.K. and Staudt, L.M. Chronic Active B Cell Receptor Signaling in Diffuse Large B Cell Lymphoma. Nature 463:88-92, 2010. PMC2845535    PubMed

Lenz, G.; Wright, G.; Dave, S.S; Xiao, W.; Powell, J.; Zhao, H.; Xu, W.; Tan, B.; Goldschmidt, N.; Iqbal, J.; Vose, J.; Bast, M.; Fu, K.; Weisenburger, D.D.; Greiner, T.C.; Armitage, J.O.; Kyle, A.; May, L.; Gascoyne, R.D.; Connors, J.M.; Troen, G.; Holte, H.; Kvaloy, S.; Dierickx, D.; Verhoef, G.; Delabie, J.; Smeland, E.B.; Jares, P.; Martinez, A.; Lopez-Guillermo, A.; Montserrat, E.; Campo, E.; Braziel, R.M.; Miller, T.P.; Rimsza, L.M.; Cook, J.; Pohlman, B.; Sweetenham, J.; Tubbs, R.R.; Fisher, R.I.; Hartmann, E.; Rosenwald, A.; Ott, G.; Muller-Hermelink, H.K.; Wrench, D.; Lister, T.A.; Jaffe, E.S.; Wilson, W.H.; Chan, W.C., and Staudt, L.M. for the Lymphoma/Leukemia Molecular Profiling Project. Stromal Gene Signatures in Large B Cell Lymphoma. New England Journal of Medicine. 359: 2313-2323, 2008.    PubMed

Lenz, G.; Wright, G.W.; Emre, T.; Kohlhammer, H.; Dave, S.S.; Davis, R.E.; Carty, S.; Lam, L.T.; Shaffer, A.L.; Xiao, W.; Powell, J.; Rosenwald, A.; Ott, G.; Muller-Hermelink, H.K.; Gascoyne, R.D.; Connors, J.M.; Campo, E.; Jaffe, E.S.; Delabie, J.; Smeland, E.B.; Rimsza, L.M.; Fisher, R.I.; Weisenburger, D.D.; Chan, W.C., and Staudt, L.M. Gene Expression Subtypes of Diffuse Large B cell lymphoma Arise by Distinct Genetic Pathways. Proceedings of the National Academy of Science. 105:135 20-5, 2008    PubMed

Lenz, G.; Davis, R.E.; Ngo, V. U.; Lam, L.; George, T.C.; Wright, G.W.; Dave, S.S.; Zhao, H.; Xu, W.; Rosenwald, A.; Ott, G.; Muller-Hermelink, H.K.; Gascoyne, R.D.; Connors, J.M.; Rimsza, L.M.; Campo, E.; Jaffe, E.S.; Delabie, J.; Smeland, E.B.; Fisher, R.I.; Chan, W.C. and Staudt, L.M. for the Leukemia Lymphoma Molecular Profiling Project. Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma. Science. 319: 1676-1679, 2008. 

Sandeep, D.S., Kai, F., Wright, G.W., Lam, L.T., Kluin, P., Boerma, E., Greiner, T.C., Weisenburger, D.D., Rosenwald, A., Ott, G., Hermelink, H.K., Gascoyne, R.D., Delabie, J., Rimsza, L.M., Braziel, R.M., Grogan, T.M., Campo, E., Jaffe, E.S., Dave, B.J., Sanger, W., Bast, M., Vose, J.M., Armitage, J.O., Connors, J.M., Smeland, E.B., Kvaloy, S., Holte, H., Fisher, R.I., Miller, T.P., Montserrat, E., Wilson, W.H., Bahl, M., Zhao, H., Yang, L., Powell, J., Simon, R., Chan, W.C., Staudt, L.M.: Molecular Diagnosis of Burkitt Lymphoma. N. Engl. J. Med. 354:2431-2442, 2006.

 Dave, S.S., Wright, G., Tan, B, Rosenwald, A., Gascoyne, R.D., Chan. W.C., Fisher, R.I., Braziel, R.M., Rimsza, L.M., Grogan, T.M., Miller, T.P., LeBlanc, M., Greiner, T.C., Weisenburger, D.D., Lynch, J.C., Vose, J., Armitage, J.O., Smeland, E.B., Kvaloy, S., Holte, H. , Delabie, J., Connors, J.M., Lansdorp, P., Ouyang, Q., Lister, T.A., Davies, A.J., Norton, A.J., Muller-Hermelink, H.K., Ott, G., Campo, E., Montserrat, E., Wilson, W.H., Jaffe, E.S., Simon, R., Yang, L.,Powell, J., Zhaol, H., Goldschmidt, N., Chiorazzi, M., Staudt, L.M. Length of survival following the diagnosis of follicular lymphoma is predicted by molecular features of non-malignant tumor infiltrating immune cells. N. Engl. J. Med 351:2159-2169, 2004.

 Rosenwald, A., Wright, G., Leroy, K., Yu, X., Gaulard, P., Gascoyne, R.D., Wing C., Chan, W.C., Zhao, H., Haioun, C., Greiner, T.C., Weisenburger, D.D., Lynch, J.C., Vose, J., Armitage, J.O., Smeland, E.B., Kvaloy, S., Holte, H., Delabie, J., Campo, E., Montserrat, E., Lopez-Guillermo, A., Ott, G., Muller-Hermelink, H.K., Connors, J.M., Braziel, R., Grogan, T.M., Fisher, R.I., Miller, T.P., LeBlanc, M., Chiorazzi, M., Zhao, H., Yang, L., Powell, J., Wilson, W.H., Jaffe, E.S., Simon, R., Klausner, R.D., and Staudt, L.M. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J. Exp. Med. 198:851-862, 2003. PMC2194208    PubMed

Rosenwald, A., Wright, G., Wiestner, A., Chan, W.C., Connors, J.M., Campo, E., Gascoyne, R.D., Grogan, T.M., Muller-Hermelink, H.K., Smeland, E.B., Chiorazzi, M., Giltnane, J.M., Hurt, E.M., Zhao, H., Averett, L., Henrickson, S., Yang, L., Powell, J., Wilson, W.H., Jaffe, E.S., Simon, R., Klausner, R.D., Montserrat, E., Bosch, F., Greiner, T.C., Weisenburger, D.D., Sanger, W.G., Dave, B.J., Lynch, J.C., Vose, J., Armitage, J.O., Fisher, R.I., Miller, T.P., LeBlanc, M., Ott, G., Kvaloy, S., Holte, H., Delabie, J. and Staudt, L.M. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell. 3:185-197, 2003.     PubMed

Rosenwald, A., Wright, G., Chan, W.C., Connors, J.M., Campo, E., Fisher, R.I., Gascoyne, R.N., Konrad Muller-Hermeliuk, H., Smeland, E.R., and Staudt, L.M. The use of molecular profiling to predict survival after chemotherapy of diffuse large B-cell lymphomas. N. Engl. J. Med. 346:1937-1947, 2002.    PubMed

Hasenclever, D., Diehl, V., Armitage, J.O., Assouline, D., Bjorkholm, M., Brusamolino, E., Canellos, G.P., Carde, P., Crowther, D., Cunningham, D., Eghbali, H., Ferme, C., Fisher, R.I., Glick, H.J., Glimelius, B., Gobbi, P.G., Holte, H., Horning, S.J., Lister, T.A., Longo, D.L., Mandelli, F., Polliack, A., Proctor, S.J., Specht, L., Sweetenham, J.W., Hudson, G.V.: A Prognostic Score for Advanced Hodgkin’s Disease. N. Engl. J.Med. 339:1506-1514, 1998.

Miller, T.P., Dahlberg, S., Cassady, J.R., Adelstein,, D.J., Spier, C.M., Grogan, T.M., LeBlanc, M., Carlin, S., Chase, E., and Fisher, R.I.: A randomized trial comparing chemotherapy alone to chemotherapy followed by radiotherapy for localized intermediate and high grade non-Hodgkin’s lymphoma. N. Engl. J. Med. 339:21-25, 1998.  

Shipp, M.A., Harrington, D.P., Anderson, J.R., Armitage, J.O., Bonnadonna, G., Brittinger, G., Cabanillas, F., Canellos, G.P., Coiffer, B., Connors, J.M., Cowan, R.A., Crowther, D., Dahlberg, S.J., Engelhard, M., Fisher, R.I., Insselbrecht, C., Horning, S.J., Lepage, E., Lister, A., Meerwaldt, J.H., Montserrat, E., Nissen, N.I., Oken, M.M., Peterson, B.A., Tondini, C., Velasquez, W.S., and Yeap, B.Y: Development of a predictive model for aggressive lymphoma: The international non-Hodgkin's lymphoma prognostic factors project. N. Engl. J. Med. 329:987-994, 1993. 

Fisher, R.I., Gaynor, E.R., Dahlberg, S., Oken, M.M., Grogan, T.M., Mize, E.M., Glick, J.H., Coltman, C.A., and Miller, T.P.: Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N. Engl. J. Med. 328:1002-1006, 1993.   PubMed

Additional Publications

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