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Biotechnology Facilities

The facilities and resources have been structured to fulfill the needs of the multi-disciplinary research programs at Fox Chase Cancer Center. These centers have been designed to enhance ongoing research by supplying information, reagents and technical expertise that are not readily available to the individual investigator.

DNA Sequencing

The DNA Sequencing Facility provides Fox Chase investigators with computer-readable sequences of their DNA templates in a timely and cost-effective manner.

High Throughput Screening

This facility provides support to investigators to pursue translational research projects by offering assay services and high throughput screening instrumentation and reagents.  The facility provides support for assay development, screen execution and secondary screening assays.  

Instrument Shop

The Instrument Shop is centrally located in room 182 of the Reimann Building and available to support the varied and diverse needs of all the clinical and scientific research staff and programs. The equipment in the facility consists of milling machines, band saw, lathes, drill press, power and foot shears, box brake, notcher, one-ton arbor press, spot welder, belt sanders welder and a dry sand blaster. A full complement of hand tools and related equipment to support the service can be found here as well.

Molecular Modeling

The Molecular Modeling Facility provides state-of-the-art services in protein sequence analysis and structure prediction to Fox Chase investigators. These services include database search; multiple sequence alignment; phylogenetic trees; secondary structure prediction; transmembrane, coiled-coil and disordered region prediction; homology modeling of single proteins and complexes; protein-protein and protein-ligand docking; and ligand design.

Organic Synthesis

This facility houses two fume hoods that provide proper ventilation of hazardous organic chemicals, and contains the following equipment: Waters Delta Prep 3000 preparative chromatography system, Nicolet 210 FT infrared spectrometer, and the usual equipment and glassware for carrying out organic syntheses. In addition, the facility has access to a Bruker Avance 300 WB NMR spectrometer for 13C, 31P and 1H analyses.

Spectroscopy Support

The primary functions of the Spectroscopy Support Facility are to maintain and operate instrumentation for high-field NMR and optical (fluorescence and circular dichroism) spectroscopy, to implement and develop methods for biomolecular studies, and to provide technical expertise and assistance to users.