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Light Microscopy Facility

Director:
Manager: 
Andrey Efimov, PhD
Andrey.Efimov@fccc.edu
215-728-5675
Reimann R379
Location             
& Phone
Reimann R379
215-728-5675
Pricing & Scheduling
Contact Andrey Efimov for pricing and scheduling.

             

The rapid pace of gene discovery over the past decade has significantly expanded efforts to characterize gene function at the molecular, biochemical and cellular levels. High resolution microscopy has become an essential component of all research programs at Fox Chase Cancer Center that are interested in characterizing gene and protein functions at the cellular and sub-cellular levels. The Light Microscopy division of the Cell Imaging Facility provides users with the equipment and knowledge to monitor cell behavior in real-time and the ability to visualize proteins inside cells with high spatial and temporal resolution. The Cell Imaging Facility is a valuable resource as it provides all Cancer Center investigators with the latest in imaging technologies, such as confocal microscopy, live imaging, and image acquisition and processing software for deconvolution microscopy, along with the expertise required to use these tools.

Isolated gills from CD4:GFP transgenic fish carrying ThPOK mutation. Images were acquired using color camera (left) and fluorescent light (right). Kappes Lab (Fox Chase Cancer Center).
Confocal 3D images of mouse large intestine (red, green) staining for the presence of bacteria (green). Koltsova Lab (Fox Chase Cancer Center).
Recruitment of NK cells (green) to kill Ectromelia virus infected cells (red) in a mouse lymph node. B cells (purple), nuclei stained with DAPI (Blue). Example of image stitching to digitally reconstruct the whole lymph node. Enlargement of boxed region is a composite of 4 channels. Sigal Lab (Fox Chase Cancer Center).
Collagen in cancer tissue sample. Image was acquired using Second Harmonic Generation method on Leica SP8 DIVE Multiphoton system. Cukierman Lab (Fox Chase Cancer Center).
7 channel staining of tissue sample using combination of regular fluorescent microscopy, Multiphoton imaging of Qdots and collagen imaging using Second Generation Harmonic. Cukierman Lab (Fox Chase Cancer Center).
MEF cells infected with Salmonella bacteria. Balachandran Lab (Fox Chase Cancer Center).

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