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Fox Chase Cancer Center News

February 15, 2019

Fox Chase Cancer Center Welcomes Psychiatrist Suzanne Doubrava

PHILADELPHIA (February 15, 2019) – A board-certified psychiatrist, Suzanne Doubrava, MD, has done extensive research on the effects of long-term psychodynamic psychotherapy for end-stage cancer patients. She comes to Fox Chase after several years in private practice.

“Our combined simulation and experimental study gives unprecedented insights into the conformational dynamics of the regulatory ACT domain of PAH and the molecular mechanism by which free Phe binds these domains,” wrote Eileen K. Jaffe, PhD.
February 13, 2019

Biomechanics of Phenylalanine Maintenance Illustrated in New Study

PHILADELPHIA (February 13, 2019) — Fox Chase Cancer Center researchers have published a groundbreaking study that describes for the first time the mechanisms of how the amount of amino acid phenylalanine (Phe) is controlled in blood. Accumulation of Phe can cause phenylketonuria (PKU), a rare genetic condition that can result in permanent neurological damage as well as behavioral abnormalities if not properly managed.

Balachandran will collaborate with researchers at Tufts University on work related to the RIPK3 enzyme.
February 7, 2019

Siddharth Balachandran Receives NIH Grant to Study Age-Related Inflammation and Injury

PHILADELPHIA (February 7, 2019) — Siddharth Balachandran, PhD, co-leader of the Blood Cell Development and Function Program at Fox Chase Cancer Center, was recently awarded a grant from the National Institute on Aging to conduct research on the process of cell death as a response to external trauma or disease. 

Robert G. Uzzo, MD, FACS
February 4, 2019

Risk-Adapted Approach to Assessing Kidney Tumor Complexity Recommended, Fox Chase Cancer Center Researchers Say

PHILADELPHIA (February 4, 2019) — By diving deep into data about more than 1,300 past kidney cancer cases, Fox Chase Cancer Center researchers concluded that there is no compelling cancer-related reason to remove an entire kidney solely based on a tumor’s location in the hilum.

Camille Ragin, PhD, MPH, associate professor in the Cancer Prevention and Control Program
January 31, 2019

More Breast Cancer Research Needed for Susceptible Caribbean Populations, Study Says

PHILADELPHIA (January 31, 2019) — Over the last four decades, detailed studies about breast cancer in Caribbean women have been limited and should be expanded, because the disease hits this population especially hard, says Camille Ragin, PhD, MPH, associate professor in the Cancer Prevention and Control Program at Fox Chase Cancer Center.

January 23, 2019

Inhibiting Cancer-Helping Enzyme May Lead to Innovative Melanoma Therapy

PHILADELPHIA (January 23, 2019) — Fox Chase Cancer Center researchers have found that inhibiting an enzyme critical to cancer cell repair and proliferation may represent a new potential strategy for treating melanoma. 

Elizabeth Handorf, PhD
January 17, 2019

New Algorithm Improves Reliability of Online Survey Data

PHILADELPHIA (January 17, 2019) — Elizabeth Handorf, PhD, has developed a new method that makes analysis of data collected online more reliable by eliminating repeat responders. 

microbiota.  Sergei Grivennikov, PhD, assistant professor in the Cancer Prevention and Control Program at Fox Chase Cancer Center, and his team investigated the role that signaling by cytokine interleukin-1 (IL-1) plays in tumor formation. They found that cytokine signals elicit distinct, cell type-specific responses, and that these responses influence the overall inflammatory tone of the tumor microenvironment and direct tumor promotion.
January 15, 2019

Research Traces Mechanisms Involving Cytokines, Inflammation, and Intestinal Microbiota that Impact Colorectal Tumor Growth

PHILADELPHIA (January 15, 2019) — Fox Chase Cancer Center researchers have found important and unexpected relationships between cytokines, tumor-elicited inflammation and the role of intestinal microbiota.

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