Jonathan Cheng, MD

Jonathan Cheng, MD
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Attending Physician

Treatment Philosophy

My practice is focused on the diagnosis, treatment and prevention of gastrointestinal malignancies. This allows me to be well versed in the multitude of complex medical, emotional and social issues facing patients. I use this experience to guide patients through the range of therapeutic options, including the latest research findings and newest clinical trials.

By understanding what patients know about themselves and their preferences, we can arrive at an appropriate treatment approach for each patient's situation. The specialized disease-focused teams at Fox Chase Cancer Center, which include pathologists, gastroenterologists, oncologic surgeons and radiation oncologists, all focused on gastrointestinal malignancies, allow for a tremendous depth of care to our patients.

Since joining Fox Chase Cancer Center in 1999, my research has focused on the importance of the surrounding support cells called stroma that tumors utilize to grow and metastasize. This has led to clinical trials investigating this novel approach using new agents that inhibit the tumor stroma in colorectal, pancreas, esophageal and gastric cancers.

Educational Background

  • Fellow, Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY
  • Fellow, Gastrointestinal Oncology, Roswell Park Cancer Institute, Buffalo, NY
  • Fellow, Laboratory Research, Fox Chase Cancer Center, Philadelphia, PA
  • Resident, Internal Medicine, University of Minnesota, Minneapolis, MN
  • MD, University of Minnesota Medical School, Minneapolis, MN, 1992


  • American Board of Internal Medicine
  • Medical Oncology 


  • American Society of Clinical Oncology
  • American Association for Cancer Research 

Maria Carosella

  • Colorectal Cancer
  • Lung Metastases

In 2002, Maria Carosella, then 36, was diagnosed with colon cancer. She had surgery at a large hospital in Philadelphia, but three weeks later when another suspicious spot appeared, she decided to make an appointment at Fox Chase Cancer Center, where she later underwent chemotherapy and surgery after finding out the cancer had spread and was lung metastases. 2018 will mark 10 years that Maria has been cancer free. "I am grateful to Fox Chase for allowing me to make it to where I am today."


Robert Kabaci

  • Esophageal Cancer

Bobby Kabaci suffered from heartburn since he was a child. Growing up, he became so used to it that it never really occurred to Bobby to go to his doctor. Bobby's mother, who worked in a doctor's office, insisted over and over that he seek medical attention. "I finally thought that if I went to the doctor, my mom would stop bugging me to go!" laughed Bobby.


Barbara Cremean

  • Stomach (Gastric) Cancer

I am quite familiar with beating the odds. In 1998, after dropping my daughters off at school, I was hit head on by a drunk driver. I was on my way to the most important meeting of my career—and my life changed in an instant. I underwent spinal fusion surgery and started the long road to recovery.


Research Interests

Tumor Microenvironment

The following ratings and reviews are based on verified feedback collected from independently administered patient experience surveys. The ratings and comments submitted by patients reflect their own views and opinions. Patient identities are withheld to ensure confidentiality and privacy. Learn more about our Patient Experience Ratings.

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