Jean-Pierre Issa, MD


Co-Leader, Cancer Epigenetics

Director, Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple University

Colorectal and SI Cancer TRDG Member

Leukemia and MDS TRDG Member

Research Program

Education, Training & Credentials

Educational Background


  • Fellowship, Medical Oncology, The Johns Hopkins University, Baltimore, MD, 1990-1994
  • Residency, Internal Medicine, The Good Samaritan Hospital, Baltimore, MD, 1987-1990
  • MD, The American University of Beirut, Beirut, Lebanon, 1987
  • BS, The American University of Beirut, Beirut, Lebanon, 1983


  • Internal Medicine, 1990
  • Medical Oncology, 1993

Honors & Awards

  • Rosenthal Award, American Association for Cancer Research, 2011
  • Faculty Achievement Award in Basic Research, M. D. Anderson Cancer Center, 2007
  • American Cancer Society Clinical Research Professorship, 2007
  • Frei Award in Translational Research from the Division of Cancer Medicine, M. D. Anderson Cancer Center, 2006
  • Election to American Society of Clinical Investigation, 2003
  • Sidney Kimmel Foundation Scholar Award, 1997
Research Profile

Research Program

Research Interests

  • Epigenomics and genomics in normal, aging and cancer cells (DNA methylation and histone modifications; genome wide genetic changes)
  • Basic mechanisms in epigenetics
  • Tumor-suppressor genes
  • Translational studies in cancer
  • Pre-clinical and clinical research in epigenetic therapy

Selected Publications

Yamazaki J, Taby R, Jelinek J, Raynal NJ, Cesaroni M, Pierce SA, Kornblau SM, Bueso-Ramos CE, Ravandi F, Kantarjian HM, Issa JP, Hypomethylation of TET2 Target Genes Identifies a Curable Subset of Acute Myeloid Leukemia. J Natl Cancer Inst 108:2()2015 Nov 13 26568194

Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL, G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci 18:12(1746-55)2015 Dec 26551542

Kopetz S, Desai J, Chan E, Hecht JR, O'Dwyer PJ, Maru D, Morris V, Janku F, Dasari A, Chung W, Issa JP, Gibbs P, James B, Powis G, Nolop KB, Bhattacharya S, Saltz L, Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer. J Clin Oncol 33:34(4032-8)2015 Dec 1 26460303

Qin T, Si J, Raynal NJ, Wang X, Gharibyan V, Ahmed S, Hu X, Jin C, Lu Y, Shu J, Estecio MR, Jelinek J, Issa JP, Epigenetic synergy between decitabine and platinum derivatives. Clin Epigenetics 7:1(97)2015 26366234.  

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