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Ekaterina Koltsova, MD, PhD

Ekaterina Koltsova, MD, PhD
About

Research Program

Localization and interactions of T cells and myeloid cells in atherosclerotic plaqu
Interactions between T cells and antigen presenting cells in the aorta
The localization of antigen presenting cells in mouse aorta
Subsets of myeloid cells in atherosclerotic plaque

 

Education and Training

Educational Background

  • PhD, Fox Chase Cancer Center (Philadelphia)/ RUDN University, Moscow, 2007
  • MD, Russian State Medical University, Moscow, 2004

Memberships

  • American Association of Immunologists (AAI)
  • American Heart Association (AHA)
  • Society for Leukocyte Biology

Honors & Awards

  • La Jolla Immunology conference (2012). The AAI Young Investigator Award.
  • Atherosclerosis thrombosis and Vascular Biology (2013). Irvine H. Page Young Investigator research award-Finalist.
Research Profile

Research Program

Research Interests

  • Immune-mediated mechanisms regulating cardiovascular diseases (CVD) development.
  • The role of anti-inflammatory cytokines in obesity, inflammation and cancer.

Lab Overview

The localization of antigen presenting cells in mouse aortaThe localization of antigen presenting cells in mouse aortaThe main role of the immune system is to protect the host from infections, by localizing and eradicating the agent and further repair of the injury site. The malfunctioning of mechanisms contributing to quenching of an activated immune response leads to persistent, non-resolving chronic inflammation, which frequently contributes to various immunopathologies. Chronic low-grade inflammation is a key component of various diseases, including cardiovascular diseases, obesity and cancer. Cardiovascular diseases (CVD), including atherosclerosis and abdominal aortic aneurysm (AAA), are a major public health threat leading to significant morbidity and mortality. A growing body of evidence demonstrated that CVD are actually chronic inflammatory diseases of the arterial wall with a large and previously underappreciated contribution of immune system into disease initiation and progression.

We have aimed to define and characterize immune–mediated mechanisms helping to regulate the inflammation in various immune-mediated pathologies such as atherosclerosis, AAA, obesity and cancer.

Subsets of myeloid cells in atherosclerotic plaqueSubsets of myeloid cells in atherosclerotic plaqueCytokines are important mediators of inflammation and are key players in auto-inflammatory diseases.  While the role of various pro-inflammatory cytokines in CVD and obesity has been extensively investigated, little is know about anti-inflammatory cytokines. IL27 is a recently discovered member of IL6/IL12 superfamily with broad anti-inflammatory role as demonstrated in models of infections. We have previously shown that IL27R signaling plays a critical role suppressing the inflammation in atherosclerosis, hence IL27R-deficient mice develop large atherosclerotic lesions due to enhanced T cell derived pro-inflammatory cytokine production. However, cell specific role of IL27R signaling remains to be defined.

Interactions between T cells and antigen presenting cells in the aortaInteractions between T cells and antigen presenting cells in the aortaObesity is associated with chronic low-grade inflammation and predisposes to many cancers, worsening their prognosis. Most notably, obesity overwhelmingly promotes liver and colon cancers but the role of anti-inflammatory cytokines (such as IL27) in the regulation of obesity-induced inflammation and obesity-promoted cancer is largely unexplored; therefore we are interested to define cellular and molecular mechanisms of IL27 contribution to these diseases pathogenesis.

 
Former Staff
  • Kien Lin, summer student
  • Shubhra  Rastogi, summer student
  • Giulia Schäefer, medical student
Lab Staff

Aliia Fatkhullina MS

Graduate Student

Room: P2151
215-728-3176

Iuliia Peshkova, MD

Graduate Student

Room: P2151
215-728-3176
Publications

Selected Publications

Koltsova E.K., Ley K.  The mysterious ways of the chemokine CXCL5.  Immunity 2010; 33:7-9.  Comment. PubMed

Koltsova E.K., Ley K.  How dendritic cells shape atherosclerosis. Trends Immunol. 2011; 32:540-47. PubMed

Sundd P., Gutierrez E., Koltsova E.K., Kuwano Y., Fukuda S., Pospieszalska M.K., Groisman A., Ley K.  'Slings' enable neutrophil rolling at high shear.  Nature 2012; 488:399-403. PubMed

Koltsova E.K., Kim G., Lloyd K.M., Saris C.J.M, von Vietinghoff, S, Kronenberg M., Ley K.  IL-27 receptor limits atherosclerosis in Ldlr-/- mice.  Circ. Res. 2012; 111:1274-85. PubMed

Koltsova E.K., Garcia Z., Chodaczek G., Landau M., McArdle S., Scott S.R., von Vietinghoff  S., Galkina E., Miller Y.I., Acton S.T., Ley K.  Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis.  J. Clin. Invest. 2012; 122:3114-26. PubMed

Koltsova E.K., Hedrick C.C., Ley K.  Myeloid cells in atherosclerosis: a delicate balance of anti-inflammatory and pro-inflammatory mechanisms.  Curr. Opin. Lipidol. 2013; 24:371-80. PubMed

Koltsova E.K., Grivennikov S.I.  IL-22 gets to the stem of colorectal cancer. Immunity 2014; 40:639-41. PubMed

Koltsova E.K., Sundd P, Zarpellon A., Ouyang H., Mikulski Z., Zampolli A, Ruggeri Z, Ley K. Genetic deletion of platelet Glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis. Thrombosis and hemostasis 2014. Dec;112(6):1252-63. PubMed

Additional Publications

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