MENU

Ekaterina Koltsova, MD, PhD

Ekaterina Koltsova, MD, PhD
About

Research Program

Koltsova Lab, 2019
Koltsova Lab, 2018
Localization and interactions of T cells and myeloid cells in atherosclerotic plaque
Interactions between T cells and antigen presenting cells in the aorta
The localization of antigen presenting cells in mouse aorta
Subsets of myeloid cells in atherosclerotic plaque
Fatkhullina et al , Immunity 2018, Cytokines link microbiota and atherosclerosis. Cover image created by Aliia Fatkhullina.
Ekaterina Koltsova, MD, PhD, Aliia Fatkhullina, MS. Immunity cover image created by Aliia Fatkhullina.

We are looking for a highly motivated postdoctoral fellow to join our team. The application can be send directly to Ekaterina Koltsova.

Education and Training

Educational Background

  • PhD, Fox Chase Cancer Center (Philadelphia)/ RUDN University, Moscow, 2007
  • MD, Russian State Medical University, Moscow, 2004

Memberships

  • American Association of Immunologists (AAI)
  • American Heart Association (AHA)
  • Society for Leukocyte Biology

Honors & Awards

  • La Jolla Immunology conference (2012). The AAI Young Investigator Award.
  • Atherosclerosis thrombosis and Vascular Biology (2013). Irvine H. Page Young Investigator research award-Finalist.
Research Profile

Research Program

Research Interests

  • Immune-mediated mechanisms regulating cardiovascular diseases (CVD) development.
  • Cytokines in the regulation of intestinal microbiota, metabolites and inflammation in cardiovascular diseases (CVD), adipose tissue inflammation and cancer
  • The role of cytokines in  stress hematopoiesis in the bone marrow: implication to CVD and cancer.
  • Cytokines,  cancer immunology and  anti-cancer immunity.

Lab Overview

The localization of antigen presenting cells in mouse aortaThe localization of antigen presenting cells in mouse aorta

The main role of the immune system is to protect the host from infections, by localizing and the eradicating of the agent and further promoting tissue repait. The malfunctioning of mechanisms contributing to quenching of activated immune response leads to persistent non-resolving chronic inflammation, which is frequently contributes to various immunopathologies. Chronic low-grade inflammation is a key component in various diseases, including cardiovascular diseases, obesity and cancer. It becoming increasingly clear that chronic inflammation can be driven by changes in microbiota composition and function, affecting the production of metabolites, which in turn  regulate the activation of various immune cells. Therefore dietory and environment factors as well as homeostasis of intestinal epithelial cells can be directly implicated into the pathogenesis of various immune-mediated diseases.

Subsets of myeloid cells in atherosclerotic plaqueSubsets of myeloid cells in atherosclerotic plaqueCardiovascular diseases (CVD), including atherosclerosis and abdominal aortic aneurysm (AAA), are major public health threat leading to significant morbidity and mortality. A growing body of evidence demonstrated that CVD are actually chronic inflammatory diseases of the arterial wall with a large and previously underappreciated contribution of immune system into disease initiation and progression.

Immune system plays a dual role in cancer: while chronic  and tumor-elicited inflammation promote tumor growth, anti-cancer immune response is crutial for cancer protection. Obesity  is associated with chronic low-grade inflammation and predisposes to many cancers, worsening their prognosis. Most notably, obesity overwhelmingly promotes liver and colon cancers.

Mechanisms regulating protective versus pathogenic function of the immunity in chronic inflammatory diseases and cancer  are not completely understood.

Interactions between T cells and antigen presenting cells in the aortaInteractions between T cells and antigen presenting cells in the aortaCytokines are  key regulators of inflammation and important players in auto-inflammatory diseases.  Cytokines play an important role in the regulation of intestinal microbiota, production of various metabolites, which in turn contribute to immune cell activation and chronic inflammation. Cytokines are also important regulators of the bone marrow hematopoietic stem cells and mature immune cells production, which represents an important arm of the immune system function.

We are interested to define and characterize the role of cytokines in the control of microbiota-driven, metabolic and cellular mechanisms helping to regulate immune cell activation and  inflammation in various immune-mediated pathologies such as atherosclerosis, AAA, obesity and cancer.

 


We are looking for a highly motivated postdoctoral fellow to join our team. The application can be send directly to Ekaterina Koltsova.

Lab Staff

Turan Aghayev, MD

Research Associate

Room: P2151
215-728-3176

Anastasia Marchenko, MS

Scientific Technician I

Room: P2151
215-728-3176

Natalia Kurilenko

Graduate Student

Room: P2151
215-728-3176

Aleksandra Mazitova, MS

Graduate Student

Room: P2151
215-728-3176

Elizaveta Titerina

Graduate Student

Room: P2151
215-728-3176

Darlene Curran

Administrative Assistant

Room: P3048
215-214-1643

Additional Staff

We are looking for a highly motivated postdoctoral fellow to join our team. The application can be send directly to Ekaterina Koltsova.

Former Staff

  • Aliia Fatkhullina, MS, graduate student 2015-2018 (PhD 2019)
  • Iuliia Peshkova, MD, graduate student 2015-2019 (expected PhD 2020)
  • Vasilisa Pozharskaya,MD, Graduate student 2017-2018
  • Kien Lin, summer student
  • Shubhra Rastogi, summer student
  • Giulia Schäefer, medical student
Publications

Selected Publications

Peshkova I.O, Aghayev T, Makhov P, Fatkhullina AR, Tan YF, Kossenkov AV, Eguchi S, Sykes S, Koltsova EK. IL27R signaling is required for Angiotensin II-induced stress hematopoiesis to promote Abdominal Aortic Aneurysm. Nature Communications. 2019 Nov 6;10(1):5046.

Immunity. 2018, 49, 1-15.Fatkhullina AR, Peshkova I.O, Dzutsev A, Aghayev T, McCulloch J.A., Thovarai V., Badger J.H.,Vats R., Sundd P., Tang H-Y, Kossenkov A.V., Hazen SL, Trinchieri, G, Grivennikov SI, Koltsova EK. An interleukin-23- interleukin-22 axis regulates intestinal microbial homeostasis to protect from diet-induced atherosclerosis. Immunity. 2018, 49, 1-15. PubMed

Peshkova I.O., Fatkhullina A.R, Mikulski Z, Ley K and Koltsova EK. IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis. Scientific Reports. 2017 May 23;7(1):2255

Peshkova I.O., Shaefer G. and Koltsova E.K. Mechanisms of Atherosclerosis and Aneurysm: is inflammation a   common denominator? FEBS J. 2016 May;283(9):1636-52. Review PubMed

Koltsova E.K., Sundd P, Zarpellon A., Ouyang H., Mikulski Z., Zampolli A, Ruggeri Z, Ley K. Genetic deletion of platelet Glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis. Thrombosis and hemostasis 2014. Dec;112(6):1252-63. PubMed

Koltsova E.K., Kim G., Lloyd K.M., Saris C.J.M, von Vietinghoff, S, Kronenberg M., Ley K.  IL-27 receptor limits atherosclerosis in Ldlr-/- mice.  Circ. Res. 2012; 111:1274-85. PubMed

Koltsova E.K., Garcia Z., Chodaczek G., Landau M., McArdle S., Scott S.R., von Vietinghoff  S., Galkina E., Miller Y.I., Acton S.T., Ley K.  Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis.  J. Clin. Invest. 2012; 122:3114-26. PubMed

Koltsova E.K., Ley K.  The mysterious ways of the chemokine CXCL5.  Immunity 2010; 33:7-9.  Comment. PubMed

Koltsova E.K., Ley K.  How dendritic cells shape atherosclerosis. Trends Immunol. 2011; 32:540-47. PubMed

Sundd P., Gutierrez E., Koltsova E.K., Kuwano Y., Fukuda S., Pospieszalska M.K., Groisman A., Ley K.  'Slings' enable neutrophil rolling at high shear.  Nature 2012; 488:399-403. PubMed

Additional Publications

My NCBI

Connect with Fox Chase