Christian A. Koch, MD, PhD, FACP, MACE

Department of Medicine > Section of Endocrinology

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Clinical Locations
About
Education and Training
Patient Stories
Research Profile
Publications

Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111

About

Director, Division of Endocrinology

Professor, Department of Medicine

Endocrinologist

Specialties

Adrenal Tumor; Head & Neck Cancer; Neuroendocrine Tumors; Thyroid Cancer

Treatment Focus

Head and Neck Tumors, Pituitary tumors, Adrenal Tumors, Neuroendocrine Tumors

Key Awards

Endocrinology, Diabetes & Metabolism

Language(s) Other than English

German

Treatment Philosophy

I am excited to be part of the multidisciplinary care at Fox Chase, and to work to improve patients' outcomes. Since endocrinology intersects with all of the other medical disciplines at Fox Chase, I get to interact daily with all my colleagues. I am truly honored to be able to help when cancer treatment affects a patient’s endocrine system. When a patient comes to see me, they can be anxious, depressed, and worried. And my goal is that they leave their appointment with a smile on their face, relieved because they know there’s a solution to it. Fox Chase has a solution to it.

Education and Training

Educational Background

DSc, University of Leipzig, “Dr.med.habilitatus”, Leipzig, Germany, 2003
Fellowship in Endocrinology, National Institutes of Health, 1998-2001
Internship and residency in Internal Medicine, Ohio State University Hospitals, Columbus, OH, 1994-97
Honorary research scholar, Royal Children’s Hospital, Dept. of Endocrinology, Melbourne, Australia, 1996
USMLE Step III, USMLE Step II, 1997
USMLE Step I (during internship/residency in the U.S.), 1995
Residency in neurology, University Hospital Jena, Jena, Germany, 1993
PhD, Westfalian-Wilhelms-University, Muenster, Germany, 1993
TOEFL (English test) and ECFMG indefinitely # 0-459-402-4, 1993
FMGEMS, Part II (clinical sciences), 1991
MD, Friedrich-Alexander University, Erlangen-Nuremberg, Germany, 1991

Certifications

Endocrinology
Internal Medicine
Diplomate, American Board of Clinical Lipidology
Lipidologist DGFF (Germany)

Memberships

Fellow of the American College of Physicians (ACP)
Master of the American College of Endocrinologists (AACE)
Member of the Southern Society of Clinical Investigation/SSCI
American Endocrine Society
American Diabetes Association
National Lipid Association
German Diabetes Association (DDG) and German Diabetologist “DDG”
German Endocrine Society

Committee Memberships

AACE Pituitary, Gonad, Adrenal and Neuroendocrine Disease State Network, 2018-
AACE Adrenal Scientific Committee (Chair: Dr. Karel Pacak), 2016-2018
Clinical Guidelines Subcommittee, Endocrine Society (Chair: Dr. Maria Fleseriu), 2015-2018
AACE (President: George Gruenberger, MD) Publications Committee, 2015-2018
AACE (President: George Gruenberger, MD) Awards Committee, 2015-2018
Southern States Chapter of AACE, Board of Directors (President: Dr. Richard Rosenthal), 2015 -2018
Council member, Southern Region AFMR (Execut. Dir: E. Chouinard, B. Wagner), 2013-
Research Committee, DoM, Univ of Miss Med Center, 2006-2008, 2009-

Honors & Awards

Philadelphia Magazine Top Doctors, 2020
Master of the American College of Endocrinology = M.A.C.E., 2017
US News Top Doctor 2011-2016
Castle Connolly America’s Top Doctors 2007-2016
The Leading Physicians of the World 2013-2016
Best of United States Physicians 2009 (bestofus.com)
Patient’s Choice Award 2013-2015
Compassionate Doctor Recognition 2013-2015
Marquis Who is Who in the World 2009, Biltmore Who’s Who 2009
Consultant of the Year Award, Dept of ENT (Chair: S. Stringer, MD), Univ of Mississippi, June 2008
O-(utstanding) professor/researcher visa in 2007 and in 2001 (see Google)
Winner International Poster Competition, ACP, San Diego, April 2003
F.A.C.P. - election in July 2002 (age 37, published academician pathway)
F.A.C.E. = Fellow of the American College of Endocrinology 5/2001
Young Investigator Award (1st place): AACE, May 2001, Texas
Resident outstanding teacher award, The Ohio State University, 1997

Patient Stories

James "Cy" Young

Melanoma

James "Cy" Young

Melanoma

Fox Chase saved my life, and they’ve given me many more years to live.

View Patient Story

Research Profile

Research Interests

Neuroendocrinology and Neuroscience
Pathogenesis of endocrine tumors incl. pituitary, adrenal, thyroid glands
Endocrine Hypertension
Endocrine Genetics and hormone resistance / insensitivity syndromes
Multiple endocrine neoplasia syndromes
Von Hippel Lindau syndrome
Adrenal tumors
Water metabolism and pituitary disorders (Cushing’s, acromegaly, others)

Publications

Selected Publications

Tharmalingam S, Reddy S, Sharda P, Koch CA. Severe Hypocalcemia and transient hypoparathyroidism after hyperthermic intraperitoneal chemotherapy. Thieme Connect 2020;Aug 7

Oktay AA, Aktürk HK, Paul TK, O'Keefe JH, Ventura HO, Koch CA, Lavie CJ. Diabetes, Cardiomyopathy, and Heart Failure. [Updated 2020 Aug 1]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.

Glasker S, Vergauwen E, Koch CA, Kutikov A, Vortmeyer AO. Von Hippel-Lindau disease: current challenges and future prospects. Onco Targets Ther 2020;June 16:13:5669-5690

Christian A.Koch, RobertoVita, SalvatoreBenvenga, The various faces of hyperthyroidism, Jnl of Clinical & Translational Endocrinology, Vol 20, June 2020, 100229

Gubbi S, Hannah-Shmouni F, Verbalis JG, Koch CA.Hypophysitis: an update on the novel forms, diagnosis and management of disorders of pituitary inflammation. Best Pract Res Clin Endocrinol Metab 2019;Dec 12:101371 doi: 10.1016/j.beem.2019.101371

Fulop T, Zsom L, Hamrahian M, Rodriguez RD, Chabrier-Rosello JO, Koch CA. Therapeutic hypernatremia management during continuous renal replacement therapy with elevated intracranial pressures and respiratory failure. Rev Endocr Metab Disord 2019;20 (1):65-75

Khan AA, Koch CA, Van Uum SHM, Baillargeon JP, Bollerslev J, Brandi ML, Marcocci C, Rejnmark L, Rizzoli R, Shrayyef MZ, Thakker RV, Yildiz BO, Clarke B. Standards of care for hypoparathyroidism in adults. Eur J Endocrinol 2019,180(3):P1-P22

Koch CA, Krabbe S, Hehmke B. Statins, metformin, proprotein-convertase-subtilisin-kexin type-9 (PCSK9) inhibitors and sex hormones: immunomodulatory properties ? Rev Endocr Metab Disord 2018, Dec (19(4):363-395

Koch CA, Petersenn S. Black swans – neuroendocrine tumors of rare locations. Rev Endocr Metab Disord 2018,Jun;19(2):107-109

Bhanat E, Koch CA, Parmar R, Garla V, Vijayakumar V. Somatostatin receptor expression in non-classical locations - clinical relevance? Rev Endocr Metab Disord. 2018 Jun;19(2):123-132

Dynkevich Y,Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J. Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory and the historical archive. Endocr Rev 2013;34(6):798-826

Fulop T, Farah Musa AR, Koch CA, Hamrahian M, Gharaibeh K, Lengvarsky Z, Pitman KT, Dixit MP. Targeted surgical parathyroidectomy in end-stage renal disease patients and longterm metabolic control: a single-center experience in the current era. Hemodial Int 2018; Jul;22(3):394-404

Kumar E, McCurdy MT, Koch CA, Hamadah A, Fulop T, Gharaibeh KA. Functional impairment of thyroid function in critically ill patients in the intensive care units. Am J Med Sci 2018; 355(3):281-285

Sindoni A, Fama F, Rosano A, Scisca C, Dionigi G, Koch CA, Gioffre-Florio M, Benvenga S. Thyroid nodules coexisting with either cystic or solid breast nodules: a new clue for this association between nodules coming from ultrasonography. Gland Surg 2017;6(6):630-637

Riley DS, Barber MS, Kienle GS, Aronson J, von Schoen-Angerer T, Tugwell P, Helfand M, Kiene H, Werthmann PG, Shamseer L, Moher D, Rison RA, Koch CA, Hanaway P, Sun GH, Altman DG, Sox H, Sudak N, Gagnier JJ. CARE 2013 explanations and elaborations: reporting guidelines for case reports. J Clin Epidemiol 2017; 89:218-235

Fleseriu M, Findling JW, Koch CA, Schlaffer SM, Buchfelder M, Gross C. Changes in plasma ACTH levels and corticotroph tumor size in patients with Cushing's disease during long-term treatment with the glucocorticoid receptor antagonist mifepristone. J Clin Endocrinol Metab 2014;99(10):3718-27

Melcescu E, Horton WB, Pitman KT, Vijayakumar V, Koch CA. Euthyroid Graves’ orbitopathy and incidental papillary thyroid microcarcinoma. Hormones (Athens) 2013; Apr 12(2):298-304

Agarwal M, Csongradi E, Koch CA, Juncos LA, Echols V, Tapolyai M, Fulop T. Severe symptomatic hypocalcemia after denusomab administration in an end-stage renal disease patient on peritoneal dialysis with controlled secondary hyperparathyroidism. Br J Med & Med Res 2013;3(4):1398-1406

Gharaibeh KA, Craig MJ, Koch CA, Lerant AA, Fulop T, Csongradi E. Desmopressin for hyponatremia overcorrection: an effective adjunct treatment for reversing rapid overcorrection and preventing osmotic demyelination syndrome. World J Clin Cases 2013;August 16; 1(5):155-158... Expand

Melcescu E, Gannon AW, Parent AD, Fratkin JF, Galhom A, Nicholas WC, Koch CA. Silent or subclinical corticotroph pituitary macroadenoma transforming into Cushing’s disease: 11-year follow-up. Neurosurgery 2013;72(1):E144-6

Saunders RN, Koch CA, Brown KB, Daley WP, Ahmed N, Vanderlan WB. Bilateral adrenal myeolipomas in a woman with chronic anticoagulation, postmenopausal uterine bleeding, primary hyperparathyroidism, and hyperthyroidism. Am J Med Sci 2013; 346(1):82-85

Melcescu E, Hogan RB, Brown K, Boyd SA, Abell TL, Koch CA. The various faces of autoimmune endocrinopathies: non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis.Exp Mol Pathol 2012;93(3):434-40

Phillips J, East HE, French SE, Melcescu E, Hamilton RD, Nicholas WC, Fratkin JF, Parent AD, Luzardo G, Koch CA. What causes a prolactinoma to be aggressive or to become a pituitary carcinoma? Hormones (Athens) 2012;11(4):477-482

Melcescu E, Phillips J, Moll G, Subauste JS, Koch CA. 11beta-hydroxylase deficiency and other syndromes of mineralocorticoid excess as a rare cause of endocrine hypertension. Horm Metab Res 2012;44(12):867-878

Fleseriu M, Biller BMK, Findling JW, Molitch ME, Schteingart DE, Gross C on behalf of the SEISMIC study investigators. Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing’s syndrome. J Clin Endocrinol Metab 2012 Jun;97(6):2039-49

Singer J, Koch CA, Kassahun W, Lamesch P, Eisenhofer G, Kluge R, Lincke T, Seiwerts M, Borte G, Schierle K, Paschke R. Pitfalls of diagnosis in a patient with a large recurrent pheochromocytoma. Nat Rev Endocrinol 2011;7(12):749-55

Singer J, Werner F, Koch CA, Bartels M, Aigner T, Lincke T, Fasshauer M, Paschke R. Ectopic Cushing’s syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. Exp Clin Endocrinol Diab 2010;118(8):524-9

Majumdar S, Friedrich CA, Koch CA, Megason GC, Fratkin JD, Moll GW. Compound heterozygous mutation with a novel splice donor region DNA sequence variant in the succinate dehydrogenase subunit B gene in a boy with malignant paraganglioma. Pediatr Blood Cancer 2010; 54(3):473-5

Baldauf C, Vortmeyer AO, Koch CA, Sticherling M. Combination of multiple skin malignancies with multiple endocrine neoplasia type 1: coincidental or pathogenetically related? Dermatology 2009;219(4):365-7

Koutlas IG, Koch CA, Vickers RA, Brouwers FM, Vortmeyer AO. An unusual ostensible example of intraoral basal cell carcinoma. J Cut Pathology 2009;36(4):464-70

Anlauf M, Bauersfeld J, Raffel A, Koch CA, et al. Insulinomatosis: a multicentric insulinoma disease that frequently causes early recurrent hyperinsulinemic hypoglycemia. Am J Surg Pathol 2009;33(3):339-46

Georgitsi M, Heliovaara E, Paschke R, Kumar AV, Tischkowitz M, Vierimaa O, Salmela P, Sane T, De Menis E, Cannavo S, Gundogdu S, Lucassen A, Izatt L,Aylwin S, Bano G, Hodgson S, Koch CA, Karhu A, Aaltonen LA. Large genomic deletions of aryl hydrocarbon receptor interacting protein (AIP)gene in pituitary adenoma predisposition. J Clin Endocrinol Metab 2008; 93(10):4146-51

Georgitsi M, Raitila A, Karhu A, van der Luijt RB, Aalfs CM, Sane T, Vierimaa O, Makinen MJ, Tuppurainen K, Paschke R, Gimm O, Koch CA, Gundogdu S, Lucassen A, Tischkowitz M, Izatt L, Aylwin S, Bano G, Hodgson S, De Menis E, Launonen V, Vahteristo P, Aaltonen LA. Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia. J Clin Endocrinol Metab 2007;92(8):3321-5

Brauer VFH, Scholz GH, Neumann S, Lohmann T, Paschke R, Koch CA. RET germline mutation in codon 791 in a family representing 3 generations from age 5 to age 70: should thyroidectomy be performed? Endocr Practice 2004;10(1):5-9

Santarpia L, Koch CA, Sarlis NJ. Hypercalcemia in cancer patients: pathobiology and management. Horm Metab Res 2010; 42(3):153-64

Koch CA, Fulop T. Clinical aspects of changes in water and sodium homeostasis in the elderly. Rev Endocr Metab Disord 2017;18(1):49-66

Koch CA, Doppman JL, Watson JC, Patronas NJ, Nieman LK. Spinal epidural lipomatosis in a patient with the ectopic corticotropin syndrome. N Engl J Med. 1999 Oct 28;341(18):1399-400

Koch CA, Pacak K, Chrousos GP. The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors. J Clin Endocrinol Metab 2002; 87: 5367-84

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Clinical Locations

Primary Location

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111

Director, Division of Endocrinology

Professor, Department of Medicine

Endocrinologist

Specialties

Adrenal Tumor; Head & Neck Cancer; Neuroendocrine Tumors; Thyroid Cancer

Treatment Focus

Head and Neck Tumors, Pituitary tumors, Adrenal Tumors, Neuroendocrine Tumors

Key Awards

Endocrinology, Diabetes & Metabolism

Language(s) Other than English

German

Treatment Philosophy

Education

Educational Background

DSc, University of Leipzig, “Dr.med.habilitatus”, Leipzig, Germany, 2003
Fellowship in Endocrinology, National Institutes of Health, 1998-2001
Internship and residency in Internal Medicine, Ohio State University Hospitals, Columbus, OH, 1994-97
Honorary research scholar, Royal Children’s Hospital, Dept. of Endocrinology, Melbourne, Australia, 1996
USMLE Step III, USMLE Step II, 1997
USMLE Step I (during internship/residency in the U.S.), 1995
Residency in neurology, University Hospital Jena, Jena, Germany, 1993
PhD, Westfalian-Wilhelms-University, Muenster, Germany, 1993
TOEFL (English test) and ECFMG indefinitely # 0-459-402-4, 1993
FMGEMS, Part II (clinical sciences), 1991
MD, Friedrich-Alexander University, Erlangen-Nuremberg, Germany, 1991

Certifications

Endocrinology
Internal Medicine
Diplomate, American Board of Clinical Lipidology
Lipidologist DGFF (Germany)

Memberships

Fellow of the American College of Physicians (ACP)
Master of the American College of Endocrinologists (AACE)
Member of the Southern Society of Clinical Investigation/SSCI
American Endocrine Society
American Diabetes Association
National Lipid Association
German Diabetes Association (DDG) and German Diabetologist “DDG”
German Endocrine Society

Committee Memberships

AACE Pituitary, Gonad, Adrenal and Neuroendocrine Disease State Network, 2018-
AACE Adrenal Scientific Committee (Chair: Dr. Karel Pacak), 2016-2018
Clinical Guidelines Subcommittee, Endocrine Society (Chair: Dr. Maria Fleseriu), 2015-2018
AACE (President: George Gruenberger, MD) Publications Committee, 2015-2018
AACE (President: George Gruenberger, MD) Awards Committee, 2015-2018
Southern States Chapter of AACE, Board of Directors (President: Dr. Richard Rosenthal), 2015 -2018
Council member, Southern Region AFMR (Execut. Dir: E. Chouinard, B. Wagner), 2013-
Research Committee, DoM, Univ of Miss Med Center, 2006-2008, 2009-

Honors & Awards

Philadelphia Magazine Top Doctors, 2020
Master of the American College of Endocrinology = M.A.C.E., 2017
US News Top Doctor 2011-2016
Castle Connolly America’s Top Doctors 2007-2016
The Leading Physicians of the World 2013-2016
Best of United States Physicians 2009 (bestofus.com)
Patient’s Choice Award 2013-2015
Compassionate Doctor Recognition 2013-2015
Marquis Who is Who in the World 2009, Biltmore Who’s Who 2009
Consultant of the Year Award, Dept of ENT (Chair: S. Stringer, MD), Univ of Mississippi, June 2008
O-(utstanding) professor/researcher visa in 2007 and in 2001 (see Google)
Winner International Poster Competition, ACP, San Diego, April 2003
F.A.C.P. - election in July 2002 (age 37, published academician pathway)
F.A.C.E. = Fellow of the American College of Endocrinology 5/2001
Young Investigator Award (1st place): AACE, May 2001, Texas
Resident outstanding teacher award, The Ohio State University, 1997

Research Profile

Research Interests

Neuroendocrinology and Neuroscience
Pathogenesis of endocrine tumors incl. pituitary, adrenal, thyroid glands
Endocrine Hypertension
Endocrine Genetics and hormone resistance / insensitivity syndromes
Multiple endocrine neoplasia syndromes
Von Hippel Lindau syndrome
Adrenal tumors
Water metabolism and pituitary disorders (Cushing’s, acromegaly, others)

Publications

Selected Publications

Tharmalingam S, Reddy S, Sharda P, Koch CA. Severe Hypocalcemia and transient hypoparathyroidism after hyperthermic intraperitoneal chemotherapy. Thieme Connect 2020;Aug 7

Glasker S, Vergauwen E, Koch CA, Kutikov A, Vortmeyer AO. Von Hippel-Lindau disease: current challenges and future prospects. Onco Targets Ther 2020;June 16:13:5669-5690

Christian A.Koch, RobertoVita, SalvatoreBenvenga, The various faces of hyperthyroidism, Jnl of Clinical & Translational Endocrinology, Vol 20, June 2020, 100229

Koch CA, Petersenn S. Black swans – neuroendocrine tumors of rare locations. Rev Endocr Metab Disord 2018,Jun;19(2):107-109

Bhanat E, Koch CA, Parmar R, Garla V, Vijayakumar V. Somatostatin receptor expression in non-classical locations - clinical relevance? Rev Endocr Metab Disord. 2018 Jun;19(2):123-132

Kumar E, McCurdy MT, Koch CA, Hamadah A, Fulop T, Gharaibeh KA. Functional impairment of thyroid function in critically ill patients in the intensive care units. Am J Med Sci 2018; 355(3):281-285

Melcescu E, Horton WB, Pitman KT, Vijayakumar V, Koch CA. Euthyroid Graves’ orbitopathy and incidental papillary thyroid microcarcinoma. Hormones (Athens) 2013; Apr 12(2):298-304

Koutlas IG, Koch CA, Vickers RA, Brouwers FM, Vortmeyer AO. An unusual ostensible example of intraoral basal cell carcinoma. J Cut Pathology 2009;36(4):464-70

Santarpia L, Koch CA, Sarlis NJ. Hypercalcemia in cancer patients: pathobiology and management. Horm Metab Res 2010; 42(3):153-64

Koch CA, Fulop T. Clinical aspects of changes in water and sodium homeostasis in the elderly. Rev Endocr Metab Disord 2017;18(1):49-66

Koch CA, Doppman JL, Watson JC, Patronas NJ, Nieman LK. Spinal epidural lipomatosis in a patient with the ectopic corticotropin syndrome. N Engl J Med. 1999 Oct 28;341(18):1399-400

Koch CA, Pacak K, Chrousos GP. The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors. J Clin Endocrinol Metab 2002; 87: 5367-84

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Fox Chase Cancer Center - Philadelphia, PA

Christian A. Koch, MD, PhD, FACP, MACE

Clinical Locations

Primary Location

Specialties

Treatment Focus

Key Awards

Language(s) Other than English

Treatment Philosophy

Educational Background

Certifications

Memberships

Committee Memberships

Honors & Awards

James "Cy" Young

James "Cy" Young

Research Interests

Selected Publications

Clinical Locations

Primary Location

Specialties

Treatment Focus

Key Awards

Language(s) Other than English

Treatment Philosophy

Education

Educational Background

Certifications

Memberships

Committee Memberships

Honors & Awards

Research Profile

Research Interests

Publications

Selected Publications

Connect with Fox Chase

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Christian A. Koch, MD, PhD, FACP, MACE

Clinical Locations

Primary Location

Specialties

Treatment Focus

Key Awards

Language(s) Other than English

Treatment Philosophy

Educational Background

Certifications

Memberships

Committee Memberships

Honors & Awards

James "Cy" Young

James "Cy" Young

Research Interests

Selected Publications

Clinical Locations

Primary Location

Specialties

Treatment Focus

Key Awards

Language(s) Other than English

Treatment Philosophy

Education

Educational Background

Certifications

Memberships

Committee Memberships

Honors & Awards

Research Profile

Research Interests

Publications

Selected Publications

Related Articles

Connect with Fox Chase