By: Fox Chase Postdoctoral Program
"Being at FCCC has been a unique opportunity to continue my previous studies on the interaction of PARP-1 and damaged chromatin. My current work focuses on how nucleosomes are remodeled by PARP-1 near double-stranded DNA breaks, which is a completely new action for PARP-1. As PARP-1 is a recently approved therapeutic target in BRCA1-deficient breast and ovarian cancer, I believe that my findings will help improve existing anti-cancer therapies."