Research at Fox Chase »Technology Transfer »Technology Licensing

The technologies listed below are available for licensing. Technologies are listed by type: Therapeutic Targets; Research Methods, Screens and Assays; Reagents; and Software.

Contact us by email, fax or by phone for licensing information.

Proton Beam Radiotherapy

• Particle Selection, Beam Monitoring and System Design for Laser-Accelerated Ion/Ion Beams for Radiotherapy (#03-12) - This invention provides significant advances in proton beam radiotherapy.
  Building an Enormous Cancer Killer [PDF]
  (Philadelphia Inquirer, 10-10-2006)

Therapeutics and Discovery Targets

Cancer

• Diagnostic Method for Early Pancreatic Cancer Detection
• Markers for Renal Cancer Diagnosis and Prognosis
• Novel Methods for Inhibiting Angiogenesis
• Markers for Early Diagnosis of Cancer
• MED1 - A Novel Gene Associated with Cancer Drug Resistance
  
• Human BUB Genes: Mitotic Checkpoint Kinases
  
• p53 repression elements in the Surviving and MAP4 promoters
  
• OVCA1 and OVCA2 Tumor Suppressor Genes
• Tumor-specific Antisense Therapy to Inhibit Bcl-2 Expression and Induce Apoptosis for Treatment of non-Hodgkin's Lymphoma
• Hef1/Cas-L, a Novel Signal Transduction Molecule Associated with Cell Motility, Growth, Apoptosis and Oncogenic Transformation [PDF]
• Pregnancy-Associated Genetic Signatures in the Human Breast
  

Antibiotics, Industrial Chemicals and Herbicides

• Morphlock-1 - A Novel Specific Inhibitor of Tetrapyrrole Biosynthesis in Plants
• Porphobilinogen Synthase - A Novel Target for Antibiotic, Industrial Chemical and Herbicide Development

HIV/AIDS

• ATR Kinase - A Novel Target for Anti-Retroviral Drug Discovery

Cancer, HIV, Urology

• MRP-Related Transporter Genes Involved in Resistance to Cytotoxic Chemotherapeutic Drugs

Research Methods, Screens, and Assays

• ELISA Assay for the Detection of Ectromelia and Vaccinia Virus Antibodies in Mice, using Recombinant Viral Proteins
  
• The Two-Hybrid Dual Bait System: An Improved Two-Hybrid System for the Detection of Protein-Protein Interactions
• A Yeast Bioassay System for the Identification of Compounds that can Lower Plasma Homocysteine Levels
• p53-Dependent Asymmetric Cell Division: A Novel Screen for Growth Regulatory Compounds
• Methods of Screening for Inhibitors of Autoinhibited Proteins
• A Novel Tumor Cell Marker for use in Evaluating Cancer Therapeutics
• A Novel Cell Cycle-Specific Kinetochore Protein that Distinguishes G2 and M-Phase Cells

Animal Models

• Fox Chase MISIIR-TAg Mouse
  - A New Model of Epithelial Ovarian Cancer

Vaccines

• Use of secreted/cell-bound poxvirus proteins (SPVP) and use thereof as vaccines and antiviral agents

Vectors, Antibodies, Reagents and Cell Lines

• Vectors
  • PGLS20 vector: A novel dual purpose vector for protein expression in E.coli and S.cerevisiae [PDF]
    
  • A Mutated Human Cytomegalovirus Expression Vector with Enhanced Ability to Express Foreign Genes
  • A Chimeric Integrase-Containing Expression Vector for Promoting Targeted Integration of Foreign DNA into a Host Genome
  • Expression vectors for MRP4 and MRP6 multidrug resistance genes
• Polyclonal Antibodies: HEPL, ATM, FAP and PIX
• Monoclonal Antibodies: MAD1/2, HIRA, ASF1a, HEF, all Bub reagents, and CENP-E
• Endonucleases
  • MED1 Glycosylase, a Tool for Detection of transition SNPs at CpG sites (CT-SNPs)
• Cell Lines
  • Murine and Human Non-Hepatic Cell Lines that support Hepatitis C Virus replication
  • Scid.adh, A Thymic Cell Line That Mimics T-Cell Development In Vitro
  • Hef1/Cas-L, a Novel Signal Transduction Molecule Associated with Cell Motility, Growth, Apoptosis and Oncogenic Transformation [PDF]

Medical Devices

• Patient Positioning Belt

Software

• ArrayExplorer^® - Image-Processing Software for cDNA Microarray Analysis

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