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2000 - present

• Beeharry N, Yen TJ. p53-dependent apoptosis in response to spindle damage linked to loss of Bub1. Cancer Biol Ther. 2009;8(7). PubMed
• Zhang XD, Goeres J, Zhang H et al. SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. Mol Cell. 2008;29(6):729-41. PubMed
• Liu ST, Yen TJ. The kinetochore as target for cancer drug development. In: PD Wulf; WC Earnshaw, editors, translator and editor The Kinetochore from Molecular Discoveries to Cancer Therapy: Springer;2008.
• Huang H, Hittle J, Zappacosta F et al. Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit. J Cell Biol. 2008;183(4):667-80. PubMed
• Huang H, Fletcher L, Beeharry N et al. Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint. Cancer Res. 2008;68(10):3724-32. PubMed
• Eytan E, Braunstein I, Ganoth D et al. Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20. Proc Natl Acad Sci USA. 2008;105(27):9181-5. PubMed
• Du J, Jablonski S, Yen TJ et al. Astrin regulates Aurora-A localization. Biochem Biophys Res Commun. 2008;370(2):213-9. PubMed
• Zuccolo M, Alves A, Galy V et al. The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J. 2007;26(7):1853-64. PubMed
• Zhang R, Liu ST, Chen W et al. HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol Cell Biol. 2007;27(3):949-62. PubMed
• Yen TJ. Polo delivers a PICH to the kinetochore. Cell. 2007;128(1):20-1. PubMed
• Sudakin V, Yen TJ. Targeting mitosis for anti-cancer therapy. BioDrugs. 2007;21(4):225-33. PubMed
• Matthew EM, Yen TJ, Dicker DT et al. Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells. Cell Cycle. 2007;6(20):2571-8. PubMed
• Huang H, Feng J, Famulski J et al. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. J Cell Biol. 2007;177(3):413-24. PubMed
• Liu ST, Rattner JB, Jablonski SA et al. Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. J Cell Biol. 2006;175(1):41-53. PubMed
• Hsu TC, Chang CH, Lin MC et al. Anti-CENP-H antibodies in patients with Sjogren's syndrome. Rheumatol Int. 2006;26(4):298-303. PubMed
• Feng J, Huang H, Yen TJ. CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay. Chromosoma 2006; 115 (4):320-9. PubMed
• Yen TJ, Kao GD. Mitotic checkpoint, aneuploidy and cancer. Adv Exp Med Biol. 2005;570:477-99. PubMed
• Robbins AR, Jablonski SA, Yen TJ et al. Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin. Cell Cycle. 2005;4(5):717-26. PubMed
• Mollinari C, Kleman JP, Saoudi Y et al. Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not. Mol Biol Cell. 2005;16(3):1043-55. PubMed
• Fletcher L, Cerniglia GJ, Yen TJ et al. Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B. Biochim Biophys Acta. 2005;1744(2):89-92. PubMed
• Chan GK, Liu ST, Yen TJ. Kinetochore structure and function. Trends Cell Biol. 2005;15(11):589-98. PubMed
• Sudakin V, Yen TJ. Purification of the mitotic checkpoint complex, an inhibitor of the APC/C from HeLa cells. Methods Mol Biol. 2004;281:199-212.
• Joseph J, Liu ST, Jablonski SA et al. The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. Curr Biol. 2004;14(7):611-7.
• Garcia-Saez I, Yen T, Wade RH et al. Crystal structure of the motor domain of the human kinetochore protein CENP-E. J Mol Biol. 2004;340(5):1107-16.
• Bertos NR, Gilquin B, Chan GK et al. Role of the tetradecapeptide repeat domain of human histone deacetylase 6 in cytoplasmic retention. J Biol Chem. 2004;279(46):48246-54. PubMed
• Williams BC, Li Z, Liu S et al. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. Mol Biol Cell. 2003;14(4):1379-91.
• Simon JA, Yen TJ. Methods in Molecular Biology. In: WS El-Deiry, editor, translator and editor Tumor Suppressor Genes: Regulation, Function, and Medicinal Applications. Vol. 223. Totowa, NJ: Humana Press; 2003.
• Simon JA, Yen TJ. Novel approaches to screen for anticancer drugs using Saccharomyces cerevisiae. Methods Mol Biol. 2003;223:555-76.
• Liu ST, van Deursen JM, Yen TJ. The role of mitotic checkpoint in maintaining genomic stability. Curr Top Dev Biol. 2003;58:27-51.
• Liu ST, Hittle JC, Jablonski SA et al. Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. Nat Cell Biol. 2003;5(4):341-5.
• Liu ST, Chan GK, Hittle JC et al. Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores. Mol Biol Cell. 2003;14(4):1638-51.
• Kao GD, McKenna WG, Guenther MG et al. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J Cell Biol. 2003;160(7):1017-27.
• Jablonski SA, Liu ST, Yen TJ. Targeting the kinetochore for mitosis-specific inhibitors. Cancer Biol Ther. 2003;2(3):236-41.
• Fletcher L, Yen TJ, Muschel RJ. DNA damage in HeLa cells induced arrest at a discrete point in G2 phase as defined by CENP-F localization. Radiat Res. 2003;159(5):604-11.
• Daniel R, Kao G, Taganov K et al. Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. Proc Natl Acad Sci USA. 2003;100(8):4778-83.
• Chan GK, Yen TJ. The mitotic checkpoint: A signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit. In: L Meijer; A Jezequel; M Roberge, editors, translator and editor Prog Cell Cycle Res; 2003; p. 431-9.
• Yen TJ. The complexity of APC/C regulation: location, location, location. Cell Cycle. 2002;1(4):2601.
• Parra MT, Page J, Yen TJ et al. Expression and behaviour of CENP-E at kinetochores during mouse spermatogenesis. Chromosoma. 2002;111(1):53-61.
• Nelson DM, Ye X, Hall C et al. Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity. Mol Cell Biol. 2002;22(21):7459-72.
• Guenther MG, Yu J, Kao GD et al. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev. 2002;16(24):3130-5.
• Chaturvedi P, Sudakin V, Bobiak ML et al. Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res. 2002;62(6):1797-801.
• Wang X, Babu JR, Harden JM et al. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. J Biol Chem. 2001;276(28):26559-67.
• Van Hooser AA, Ouspenski, II, Gregson HC et al. Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J Cell Sci. 2001;114(Pt 19):3529-42.
• Sudakin V, Chan GK, Yen TJ. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol. 2001;154(5):925-36.
• McEwen BF, Chan GK, Zubrowski B et al. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol Biol Cell. 2001;12(9):2776-89.
• Marmorstein LY, Kinev AV, Chan GK et al. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. Cell. 2001;104(2):247-57.
• Kao GD, McKenna WG, Yen TJ. Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells. Oncogene. 2001;20(27):3486-96.
• Hoffman DB, Pearson CG, Yen TJ et al. Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores. Mol Biol Cell. 2001;12(7):1995-2009.
• Daniel R, Katz RA, Merkel G et al. Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses. Mol Cell Biol. 2001;21(4):1164-72.
• Crespo NC, Ohkanda J, Yen TJ et al. The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. J Biol Chem. 2001;276(19):16161-7.
• Campbell MS, Chan GK, Yen TJ. Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase. J Cell Sci. 2001;114(Pt 5):953-63.
• Sugata N, Li S, Earnshaw WC et al. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes. Hum Mol Genet. 2000;9(19):2919-26.
• Starr DA, Saffery R, Li Z et al. HZwint-1, a novel human kinetochore component that interacts with HZW10. J Cell Sci. 2000;113( Pt 11):1939-50.
• Chan GK, Jablonski SA, Starr DA et al. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. Nat Cell Biol. 2000;2(12):944-7.

1990 - 1999

• Chan GK, Jablonski SA, Sudakin V et al. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J Cell Biol. 1999;146(5):941-54.
• Zecevic M, Catling AD, Eblen ST et al. Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E. J Cell Biol. 1998;142(6):1547-58.
• Liu SC, Sauter ER, Clapper ML et al. Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity. Cancer Epidemiol Biomarkers Prev. 1998;7(7):597-603.
• Jablonski SA, Chan GK, Cooke CA et al. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromosoma. 1998;107(6-7):386-96.
• Gately DP, Hittle JC, Chan GK et al. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Mol Biol Cell. 1998;9(9):2361-74.
• Chan GK, Schaar BT, Yen TJ. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J Cell Biol. 1998;143(1):49-63.
• Basu J, Logarinho E, Herrmann S et al. Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod. Chromosoma. 1998; .107(6-7):376-85.
• Zhang N, Chen P, Khanna KK et al. Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. Proc Natl Acad Sci USA. 1997;94(15):8021-6.
• Shafman T, Khanna KK, Kedar P et al. Interaction between ATM protein and c-Abl in response to DNA damage. Nature. 1997;387(6632):520-3.
• Schaar BT, Chan GK, Maddox P et al. CENP-E function at kinetochores is essential for chromosome alignment. J Cell Biol. 1997;139(6):1373-82.
• Cooke CA, Schaar B, Yen TJ et al. Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase. Chromosoma. 1997;106(7):446-55.
• Yen TJ, Schaar BT. Kinetochore function: molecular motors, switches and gates. Curr Opin Cell Biol. 1996;8(3):381-8.
• Yen TJ. Motor proteins in mitosis and meiosis. In: JE Hesketh; ZF Pryme, editors, translator and editor The Cytoskeleton: Structure and Assembly. Vol. 1: JAI; 1995; p. 87-122.
• Thrower DA, Jordan MA, Schaar BT et al. Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor. EMBO J. 1995;14(5):918-26.
• Lombillo VA, Nislow C, Yen TJ et al. Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro. J Cell Biol. 1995;128(1-2):107-15.
• Liao H, Winkfein RJ, Mack G et al. CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. J Cell Biol. 1995;130(3):507-18.
• Testa JR, Zhou JY, Bell DW et al. Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization. Genomics. 1994;23(3):691-3.
• Liao H, Li G, Yen TJ. Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein. Science. 1994;265(5170):394-8.
• Brown KD, Coulson RM, Yen TJ et al. Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis. J Cell Biol. 1994;125(6):1303-12.
• Rattner JB, Rao A, Fritzler MJ et al. CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. Cell Motil Cytoskeleton. 1993;26(3):214-26.
• Yen TJ, Li G, Schaar BT et al. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature 1992; 359 (6395):536-9.
• Yen TJ, Compton DA, Wise D et al. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J. 1991;10(5):1245-54.
• Compton DA, Yen TJ, Cleveland DW. Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds. J Cell Biol. 1991;112(6):1083-97.
• Gabriel A, Yen TJ, Schwartz DC et al. A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata. Mol Cell Biol. 1990;10(2):615-24.

1980 - 1989

• Cleveland DW, Yen TJ. Multiple determinants of eukaryotic mRNA stability. New Biol. 1989;1(2):121-6.
• Yen TJ, Machlin PS, Cleveland DW. Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. Nature. 1988;334(6183):580-5.
• Yen TJ, Gay DA, Pachter JS et al. Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides. Mol Cell Biol. 1988;8(3):1224-35.
• Pachter JS, Yen TJ, Cleveland DW. Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell. 1987;51(2):283-92.
• Joshi HC, Yen TJ, Cleveland DW. In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function. J Cell Biol. 1987;105(5):2179-90.
• Gay DA, Yen TJ, Lau JT et al. Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA. Cell. 1987;50(5):671-9.