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Andres J.P. Klein-Szanto, MD, PhD
Andres Klein-Szanto, MD, PhD
Professor
  • Director, Histopathology Facility
Andres.Klein-Szanto@fccc.edu
Office Phone: 215-728-3154
Fax: 215-728-2899
Office: C417
Lab: C417

2000 - present

  • Shatalova E, Klein-Szanto AJ, Devarajan K, Cukierman E, Clapper M. Estrogen and Cytochrome P450 1B1 contribute to both early-and late-stage head and neck. Cancer Prevention Res. 2011; 4:107-115.
  • Schonrath K, Pan W, Klein-Szanto AJ, Braunewell KH. Involvement of VILIP-1 and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma. Molec. Carcinogenesis 2011;50:319-333.
  • Fedele M, Visone R, De Martino I, Palmieri D, Valentino T, Esposito F, Klein-Szanto AJ, Arra C, Ciarmiello A, Croce CM, Fusco A. Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice. Eur. J. Cancer 2011; 47:470-478.
  • Rudnick S, Lou J, Shaller C, Tang Y, Klein-Szanto AJ, Weiner L, Marks J, Adams G. Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors. Cancer Res. 2011;71:2250-9.
  • Frank AK, Leu JI, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto AJ, Hollstein M, Murphy ME. The codon 72 polymorphism of p53 regulates interaction with NF-kB and transactivation of genes involved in immunity and inflammation. Mol. Cell Biol. 2011;31:1201-1213.
  • Stairs DB, Bayne L, Rhoades B, Vega ME, Waldron T, Kalabis J, Klein-Szanto AJ, Lee S, Katz J, Diehl A, Reynolds A, Vonderheide R, Rustgi AK. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a bona fide tumor suppressor. Cancer Cell 2011;19:470-483.
  • Altomare DA, Menges CW, Xu J, Pei J, Zhang L, Tadevosyan A, Neumann-Domer E, LiuZ, Carbone M, Chudoba I, Klein-Szanto AJ, Testa JR. Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS ONE 2011;6(4):e18828.
  • Hopper-Borge EA, Churchill T, Paulose C, Nicolas E, Jacobs, J, Ngo O, Kuang Y, Grinberg A, Westphal H, Chen Z, Klein-Szanto AJ, Belinsky M, Kruh GD. Contribution of Abcc10 (Mrp7) to in vico Paclitaxel resistance as addressed in Abcc10-/- mice. Cancer Res. 2011;71:3649-3657.
  • Goetz JG, Minguet S, Navarro-Leridal, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibanez T, Pellinen T, Echarri A, Klein-Szanto AJ, Garcia R, Keely P, Sanchez-Mateos P, Cukierman E, Del Pozo MA. Regulation of the biomechanical properties of the tumor microenvironment by stromal Caveolin-1 promotes invasion. Cell (in press).
  • Ohashi S, Natsuizaka M, Yashior-Ohtani Y, Kalman RA, Nakagawa M, Wu L, Klein-Szanto AJ, Herlyn M, Diehl JA, Katz JP, Pear WS, Seykora JT, Nakagawa H. NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology 2011;139:2113-2123.
  • Tetreault MP, Wang ML, Yang Y, Travis J, Yu QC, Klein-Szanto AJ, Katz JP. Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology 2010; 139:2124-2134.
  • Singh MK, Izumchencko E, Klein-Szanto AJ, Egleston BL, Wolfson M, Golemis EA. Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking Nedd9. Cancer Res. 2010;70:8907-8916.
  • Sosa MS, Yang C, Lopez-Haber C, Lemmon M, Benovic M, Klein-Szanto AJ, Yagi H, Gutkind JS, Lefebvre C, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Molecular Cell 2010; 40:877-892.
  • Quinn BA, Xiao F, Bickel L, Martin L, Hua X, Klein-Szanto AJ, Connolly DC. Development of a syngeneic mouse model of epithelial ovarian cancer. J. Ovarian Res. 2010; 3:24.
  • Balaburski GM, Dardes RC, Johnson M, Haddad B, Zhu F, Ross EA, Sengupta S, Klein-Szanto A, Liu H, Lee ES, Kim H, Jordan VC. Raloxifene-stimulated experimental breast cancer with the paradoxical actions of estrogen to promote or prevent tumor growth: a unifying concept in anti-hormone resistance. Int J Oncol. 2010 Aug;37(2):387-98. PubMed
  • Mabuchi S, Kawase C, Altomare DA, Morishige K, Hayashi M, Sawada K, Ito K, Terai Y, Nishio Y, Klein-Szanto AJ, Burger RA, Ohmichi M, Testa JR, Kimura T. Vascular endothelial growth factor is a promising therapeutic target for the treatment of clear cell carcinoma of the ovary. Mol Cancer Ther. 2010 Aug;9(8):2411-22. Epub 2010 Jul 27. PubMed
  • Grugan KD, Miller CG, Yao Y, Michaylira CZ, Ohashi S, Klein-Szanto AJ, Diehl JA, Herlyn M, Han M, Nakagawa H, Rustgi AK. Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11026-31. PubMed
  • Michaylira CZ, Wong GS, Miller CG, Gutierrez CM, Nakagawa H, Hammond R, Klein-Szanto AJ, Lee JS, Kim SB, Herlyn M, Diehl JA, Gimotty P, Rustgi AK. Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer. Cancer Res. 2010 Jul 1;70(13):5281-92. PubMed
  • Natsuizaka M, Ohashi S, Wong GS, Ahmadi A, Kalman RA, Budo D, Klein-Szanto AJ, Herlyn M, Diehl JA, Nakagawa H. Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells. Carcinogenesis. 2010 Aug;31(8):1344-53. PubMed
  • Ohashi S, Natsuizaka M, Wong GS, Michaylira CZ, Grugan KD, Stairs DB, Kalabis J, Vega ME, Kalman RA, Nakagawa M, Klein-Szanto AJ, Herlyn M, Diehl JA, Rustgi AK, Nakagawa H. Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Res. 2010 May 15;70(10):4174-84. PubMed
  • Bassi DE, Zhang J, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ. Proprotein Convertase Inhibition Results in Decreased Skin Cell Proliferation, Tumorigenesis, and Metastasis. Neoplasia. 2010 Jul;12(7):516-26. PubMed
  • Tetreault MP, Yang Y, Travis J, Yu QC, Klein-Szanto A, Tobias JW, Katz JP. Esophageal squamous cell dysplasia and delayed differentiation with deletion of kr�ppel-like factor 4 in murine esophagus. Gastroenterology. 2010 Jul;139(1):171-81.e9. Epub 2010 Mar 27. PubMed
  • Haenssen K, Caldwell S, Shahriari K, Jackson S, Whelan KA, Klein-Szanto AJ, and Reginato MJ. ErbB2 requires integrin {alpha}5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells. J Cell Sci. 2010;123:1373-82.
  • Fu J, Fong K, Bellacosa A, Ross E, Apostolou S, Bassi DE, Jin F, Zhang J, Cairns P, Iba�ez de Caceres I, Braunewell KH, Klein-Szanto AJ. VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival. PLoS One. 2008 Feb 27;3(2):e1698. PubMed
  • Patel RR, Sengupta S, Kim HR, Klein-Szanto AJ, Pyle JR, Zhu F, Li T, Ross EA, Oseni S, Fargnoli J, Jordan VC. Experimental treatment of oestrogen receptor (ER) positive breast cancer with tamoxifen and brivanib alaninate, a VEGFR-2/FGFR-1 kinase inhibitor: a potential clinical application of angiogenesis inhibitors.Eur J Cancer. 2010 Jun;46(9):1537-53. PubMed
  • von Holzen U, Chen T, Boquoi A, Richter JE, Falk GW, Klein-Szanto AJ, Cooper H, Litwin S, Weinberg DS, Enders GH. Evidence for DNA damage checkpoint activation in Barrett’s esophagus. Transl Oncol. 2010 Feb;3(1):33-42. PubMed
  • Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, Naomoto Y, Klein-Szanto AJ, Haase VH, Nakagawa H. Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis. 2010 Mar;31(3):427-34. PubMed
  • Altomare DA, Zhang L, Deng J, Di Cristofano A, Klein-Szanto AJ, Kumar R, Testa JR. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res. 2010 Jan 15;16(2):486-96. PubMed
  • Sauter ER, Klein-Szanto A, MacGibbon B, Ehya H. Nipple aspirate fluid and ductoscopy to detect breast cancer. Diag. Cytopathol. 2010;38:244-51.
  • Fu J, Zhang J, Jin F, Patchefsky J, Braunewell KH, Klein-Szanto AJ. Promoter regulation of the visinin-like subfamily of neuronal calciumsensor proteins by nuclear respiratory factor-1. J Biol Chem. 2009 Oct 2;284(40):27577-8. PubMed
  • Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009 Sep 15;69(18):7198-206. PubMed
  • Gumireddy K, Li A, Gimotty PA, Klein-Szanto AJ, Showe LC, Katsaros D, Coukos G, Zhang L, Huang Q. KLF17 is a negative regulator of epithelial-mesenchimal transition and metastasis in breast cancer. Nat Cell Biol. 2009 Nov;11(11):1297-304. PubMed
  • Kadariya Y, Yin B, Tang B, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (/MTAP/) die prematurely of T-cell lymphoma. Cancer Res. 2009 Jul 15;69(14):5961-9. PubMed
  • Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Hayashi M, Tsujimoto M, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa JR, Kimura T. mTOR is a promising target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary. Clin Cancer Res. 2009 Sep 1;15(17):5404-13. PubMed
  • Cai KQ, Caslini C, Capo-chichi CD, Slater C, Smith ER, Wu H, Klein-Szanto AJ, Godwin AK, Xu XX. Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia. PLoS One. 2009 Jul 31;4(7):e6454. PubMed
  • Seiwert TY, Jagadeeswaran R, Faoro L, Janamanchi V, Nallasura V, El Dinali M, Yala S, Kanteti R, Cohen EE, Lingen MW, Martin L, Krishnaswamy S, Klein-Szanto A, Christensen JG, Vokes EE, Salgia R. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 2009 Apr 1;69(7):3021-31. Epub 2009 Mar 24. PubMed
  • Hartman TR, Nicolas E, Klein-Szanto A, Al-Saleem T, Cash TP, Simon MC, Henske EP. The role of the Birt-Hogg-Dub� protein in mTOR activation and renal tumorigenesis. Oncogene. 2009 Apr 2;28(13):1594-604. Epub 2009 Feb 23. PubMed
  • Cai KQ, Wu H, Klein-Szanto AJ, Xu XX. Acquisition of a second mutation of the Tp53 alleles immediately precedes epithelial morphological transformation in ovarian tumorigenicity. Gynecol Oncol. 2009 Jul;114(1):18-25. Epub 2009 Apr 16. PubMed
  • Gupta S, K�hnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD. Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J. 2009 Mar;23(3):883-93. Epub 2008 Nov 5. PubMed
  • Braunewell KH, Klein-Szanto AJ. Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2 -sensor proteins. Cell Tissue Res. 2009 Feb;335(2):301-16. Epub 2008 Nov 7. Review. Erratum in: Cell Tissue Res. 2009 May;336(2):345. Szanto, Andres J Klein [corrected to Klein-Szanto, Andres J]. PubMed
  • Lewis-Wambi JS, Kim HR, Wambi C, Patel R, Pyle JR, Klein-Szanto AJ, Jordan VC. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Res. 2008;10(6):R104. Epub 2008 Dec 5. PubMed
  • Stairs DB, Nakagawa H, Klein-Szanto A, Mitchell SD, Silberg DG, Tobias JW, Lynch JP, Rustgi AK. Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus. PLoS One. 2008;3(10):e3534. PubMed
  • Lioni M, Noma K, Snyder A, Klein-Szanto A, Diehl JA, Rustgi AK, Herlyn M, Smalley KS. Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway. Mol Cancer Ther. 2008 Sep;7(9):2866-75. PubMed
  • Schilder RJ, Sill MW, Lee RB, Shaw TJ, Senterman MK, Klein-Szanto AJ, Miner Z, Vanderhyden BC. Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2008 Jul 10;26(20):3418-25. PubMed
  • Fu J, Fong K, Bellacosa A, Ross E, Apostolou S, Bassi DE, Jin F, Zhang J, Cairns P, Iba�ez de Caceres I, Braunewell KH, Klein-Szanto AJ. VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival. PLoS ONE. 2008 Feb 27;3(2):e1698. PubMed
  • Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan DA, Li A, Huang G, Klein-Szanto AJ, Gimotty PA, Katsaros D, Coukos G, Zhang L, Pur� E, Agami R. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol. 2008 Feb;10(2):202-10. Epub 2008 Jan 13. PubMed
  • Finnberg N, Klein-Szanto AJ, El-Deiry WS. TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin Invest. 2008 Jan;118(1):111-23. PubMed
  • Aggarwal P, Lessie MD, Lin DI, Pontano L, Gladden AB, Nuskey B, Goradia A, Wasik MA, Klein-Szanto AJ, Rustgi AK, Bassing CH, Diehl JA. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev. 2007 Nov 15;21(22):2908-22. PubMed
  • Okawa T, Michaylira CZ, Kalabis J, Stairs DB, Nakagawa H, Andl CD, Johnstone CN, Klein-Szanto AJ, El-Deiry WS, Cukierman E, Herlyn M, Rustgi AK. The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev. 2007 Nov 1;21(21):2788-803. PubMed
  • Macias E, Kim Y, Miliani de Marval PL, Klein-Szanto A, Rodriguez-Puebla ML. Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. Cancer Res. 2007 Oct 15;67(20):9713-20. PubMed
  • Page RE, Klein-Szanto AJ, Litwin S, Nicolas E, Al-Jumaily R, Alexander P, Godwin AK, Ross EA, Schilder RJ, Bassi DE. Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer. Cell Oncol. 2007;29(4):289-99. PubMed
  • Garland LL, Rankin C, Gandara DR, Rivkin SE, Scott KM, Nagle RB, Klein-Szanto AJ, Testa JR, Altomare DA, Borden EC. Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study. J Clin Oncol. 2007 Jun 10;25(17):2406-13. PubMed
  • Xu RH, Fang M, Klein-Szanto A, Sigal LJ. Memory CD8 T cells are gatekeepers of the lymph node draining the site of viral infection. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10992-7. Epub 2007 Jun 19.PubMed
  • Takaoka M, Kim SH, Okawa T, Michaylira CZ, Stairs DB, Johnstone CN, Andl CD, Rhoades B, Lee JJ, Klein-Szanto AJ, El-Deiry WS, Nakagawa H. IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. Cancer Biol Ther. 2007 Apr;6(4):534-40. PubMed
  • Yang WL, Cai KQ, Smedberg JL, Smith ER, Klein-Szanto A, Hamilton TC, Xu XX. A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. Am J Pathol. 2007 Apr;170(4):1325-36. PubMed
  • de Cicco RL, Bassi DE, Benavides F, Conti CJ, Klein-Szanto AJ. Inhibition of proprotein convertases: approaches to block squamous carcinoma development and progression. Mol Carcinog. 2007 Aug;46(8):654-9. Review. PubMed
  • Gumireddy K, Sun F, Klein-Szanto AJ, Gibbins JM, Gimotty PA, Saunders AJ, Schultz PG, Huang Q. In vivo selection for metastasis promoting genes in the mouse. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6696-701. Epub 2007 Apr 9. PubMed
  • Wang Y, Ylera F, Boston M, Kang SG, Kutok JL, Klein-Szanto AJ, Junghans RP. Focused antibody response in plasma cell-infiltrated non-medullary (NOS) breast cancers. Breast Cancer Res Treat. 2007 Aug;104(2):129-44. Epub 2007 Mar 28. PubMed
  • Oyama K, Okawa T, Nakagawa H, Takaoka M, Andl CD, Kim SH, Klein-Szanto A, Diehl JA, Herlyn M, El-Deiry W, Rustgi AK. AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene. 2007 Apr 5;26(16):2353-64. PubMed
  • Henry LR, Lee HO, Lee JS, Klein-Szanto A, Watts P, Ross EA, Chen WT, Cheng JD. Clinical implications of fibroblast activation protein in patients with colon cancer. Clin Cancer Res. 2007 Mar 15;13(6):1736-41. PubMed
  • Mabuchi S, Altomare DA, Connolly DC, Klein-Szanto A, Litwin S, Hoelzle MK, Hensley HH, Hamilton TC, Testa JR. RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res. 2007 Mar15;67(6):2408-13. PubMed
  • Yeager N, Klein-Szanto A, Kimura S, Di Cristofano A. Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Res. 2007 Feb 1;67(3):959-66. PubMed
  • Sauter ER, Wagner-Mann C, Ehya H, Klein-Szanto A. Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings. Cancer Detect Prev. 2007;31(1):50-8. Epub 2007 Feb 20. PubMed
  • Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP. Activation of the mTOR signaling pathway in renal clear cell carcinoma. J Urol. 2007 Jan;177(1):346-52. PubMed
  • Belinsky MG, Guo P, Lee K, Zhou F, Kotova E, Grinberg A, Westphal H, Shchaveleva I, Klein-Szanto A, Gallo JM, Kruh GD. Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res. 2007 Jan 1;67(1):262-8. PubMed
  • Klein WM, Wu BP, Zhao S, Wu H, Klein-Szanto AJ, Tahan SR. Increased expression of stem cell markers in malignant melanoma. Mod Pathol. 2007 Jan;20(1):102-7. Epub 2006 Nov 24. PubMed
  • Yu Y, Fan J, Hui Y, Rouzer CA, Marnett LJ, Klein-Szanto AJ, FitzGerald GA, Funk CD. Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. J Biol Chem. 2007 Jan 12;282(2):1498-506. Epub 2006 Nov 16. PubMed
  • Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell. 2006 Nov 3;24(3):355-66.
  • Cai KQ, Klein-Szanto A, Karthik D, Edelson M, Daly MB, Ozols RF, Lynch HT, Godwin AK, Xu XX. Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations. Gynecol Oncol. 2006 Nov;103(2):719-28. PubMed
  • Kim SH, Nakagawa H, Navaraj A, Naomoto Y, Klein-Szanto AJ, Rustgi AK, El-Deiry WS. Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras. Cancer Res. 2006 Nov 1;66(21):10415-24. PubMed
  • Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK. Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo. Cancer Res. 2006 Oct 15;66(20):9878-85. PubMed
  • Jones-Bolin S, Zhao H, Hunter K, Klein-Szanto A, Ruggeri B. The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice. Mol Cancer Ther. 2006 Jul;5(7):1744-53. PubMed
  • Yang DH, Fazili Z, Smith ER, Cai KQ, Klein-Szanto A, Cohen C, Horowitz IR, Xu XX. Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background. Am J Pathol. 2006 Jul;169(1):258-67. PubMed
  • Yu Y, Fan J, Chen XS, Wang D, Klein-Szanto AJ, Campbell RL, FitzGerald GA, Funk CD. Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Nat Med. 2006 Jun;12(6):699-704. Epub 2006 May 28. PubMed
  • Chen Y, Weeks RS, Burns MR, Boorman DW, Klein-Szanto A, O'Brien TG. Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma. Int J Cancer. 2006 May 1;118(9):2344-9. PubMed
  • Vilgelm A, Lian Z, Wang H, Beauparlant SL, Klein-Szanto A, Ellenson LH, Di Cristofano A. Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten /- mice. Cancer Res. 2006 Apr 1;66(7):3375-80. PubMed
  • Wickborn C, Klein-Szanto AJ, Schlag PM, Braunewell KH. Correlation of visinin-like-protein-1 expression with clinicopathological features in squamous cell carcinoma of the esophagus. Mol Carcinog. 2006 Aug;45(8):572-81. PubMed
  • Fedele M, Fidanza V, Battista S, Pentimalli F, Klein-Szanto AJ, Visone R, De Martino I, Curcio A, Morisco C, Del Vecchio L, Baldassarre G, Arra C, Viglietto G, Indolfi C, Croce CM, Fusco A. Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res. 2006 Mar 1;66(5):2536-43. PubMed
  • Bassi DE, Fu J, Lopez de Cicco R, Klein-Szanto AJ. Proprotein convertases: master switches in the regulation of tumor growth and progression. Mol Carcinog. 2005 Nov;44(3):151-61. Review. PubMed
  • Khatib AM, Bassi D, Siegfried G, Klein-Szanto AJ, Ouafik L. Endo/exo-proteolysis in neoplastic progression and metastasis. J Mol Med. 2005 Nov;83(11):856-64. Epub 2005 Aug 26. Review. PubMed
  • Bassi DE, Lopez De Cicco R, Cenna J, Litwin S, Cukierman E, Klein-Szanto AJ. PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression. Cancer Res. 2005 Aug 15;65(16):7310-9. PubMed
  • Amatangelo MD, Bassi DE, Klein-Szanto AJ, Cukierman E. Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol. 2005 Aug;167(2):475-88. PubMed
  • Wang L, Chen X, Tang B, Hua X, Klein-Szanto A, Kruger WD. Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Hum Mol Genet. 2005 Aug 1;14(15):2201-8. PubMed
  • Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M, Broccoli D. Multiple mechanisms of telomere maintenance exist in liposarcomas. Clin Cancer Res. 2005 Aug 1;11(15):5347-55. PubMed
  • Belinsky MG, Dawson PA, Shchaveleva I, Bain LJ, Wang R, Ling V, Chen ZS, Grinberg A, Westphal H, Klein-Szanto A, Lerro A, Kruh GD. Analysis of the in vivo functions of Mrp3. Mol Pharmacol. 2005 Jul;68(1):160-8. PubMed
  • Nunez MI, Rosen DG, Ludes-Meyers JH, Abba MC, Kil H, Page R, Klein-Szanto AJ, Godwin AK, Liu J, Mills GB, Aldaz CM. WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer. 2005 Jun 27;5:64. PubMed
  • L�pez de Cicco R, Bassi DE, Zucker S, Seidah NG, Klein-Szanto AJ. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer Res. 2005 May 15;65(10):4162-71. PubMed
  • Guo S, Hakimi MA, Baillat D, Chen X, Farber MJ, Klein-Szanto AJ, Cooch NS, Godwin AK, Shiekhattar R. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res. 2005 Apr 15;65(8):3011-6. PubMed
  • Yu Y, Cheng Y, Fan J, Chen XS, Klein-Szanto A, Fitzgerald GA, Funk CD. Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. J Clin Invest. 2005 Apr;115(4):986-95. PubMed
  • Gonzalez Guerrico AM, Jaffer ZM, Page RE, Braunewell KH, Chernoff J, Klein-Szanto AJ. Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene. 2005 Mar 31;24(14):2307-16. PubMed
  • Fedele M, Pentimalli F, Baldassarre G, Battista S, Klein-Szanto AJ, Kenyon L, Visone R, De Martino I, Ciarmiello A, Arra C, Viglietto G, Croce CM, Fusco A. Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene. 2005 May 12;24(21):3427-35. PubMed
  • Nunez MI, Ludes-Meyers J, Abba MC, Kil H, Abbey NW, Page RE, Sahin A, Klein-Szanto AJ, Aldaz CM. Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status. Breast Cancer Res Treat. 2005 Jan;89(2):99-105. PubMed
  • Sauter ER, Ehya H, Klein-Szanto AJ, Wagner-Mann C, MacGibbon B. Fiberoptic ductoscopy findings in women with and without spontaneous nipple discharge. Cancer. 2005 Mar 1;103(5):914-21. PubMed
  • Wu H, Barusevicius A, Babb J, Klein-Szanto A, Godwin A, Elenitsas R, Gelfand JM, Lessin S, Seykora JT. Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential. J Cutan Pathol. 2005 Feb;32(2):125-30. PubMed
  • Stewart SL, Querec TD, Ochman AR, Gruver BN, Bao R, Babb JS, Wong TS, Koutroukides T, Pinnola AD, Klein-Szanto A, Hamilton TC, Patriotis C. Characterization of a carcinogenesis rat model of ovarian preneoplasia and neoplasia. Cancer Res. 2004 Nov 15;64(22):8177-83. PubMed
  • Purev E, Cai D, Miller E, Swoboda R, Mayer T, Klein-Szanto A, Marincola FM, Mick R, Otvos L, Wunner W, Birebent B, Somasundaram R, Wikstrand CJ, Bigner D, DeMichele A, Acs G, Berlin JA, Herlyn D. Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R). J Immunol. 2004 Nov 15;173(10):6472-80. PubMed
  • Balsara BR, Pei J, Mitsuuchi Y, Page R, Klein-Szanto A, Wang H, Unger M, Testa JR. Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis. 2004 Nov;25(11):2053-9. PubMed
  • Takaoka M, Harada H, Andl CD, Oyama K, Naomoto Y, Dempsey KL, Klein-Szanto AJ, El-Deiry WS, Grimberg A, Nakagawa H. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res. 2004 Nov 1;64(21):7711-23. PubMed
  • Sauter ER, Klein-Szanto A, Ehya H, MacGibbon B. Ductoscopic cytology and image analysis to detect breast carcinoma. Cancer. 2004 Sep 15;101(6):1283-92. PubMed
  • Adams GP, Shaller CC, Dadachova E, Simmons HH, Horak EM, Tesfaye A, Klein-Szanto AJ, Marks JD, Brechbiel MW, Weiner LM. A single treatment of yttrium-90-labeled CHX-A-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice. Cancer Res. 2004 Sep 1;64(17):6200-6. PubMed
  • L�pez de Cicco R, Watson JC, Bassi DE, Litwin S, Klein-Szanto AJ. Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression. Clin Cancer Res. 2004 Jul 1;10(13):4480-8. PubMed
  • Chen Y, Hu J, Boorman D, Klein-Szanto A, O'Brien TG. Therapy of murine squamous cell carcinomas with 2-difluoromethylornithine. J Carcinog. 2004 Jun 2;3(1):10. PubMed
  • Krassenstein R, Sauter E, Dulaimi E, Battagli C, Ehya H, Klein-Szanto A, Cairns P. Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):28-32. PubMed
  • Ruggeri B, Singh J, Gingrich D, Angeles T, Albom M, Yang S, Chang H, Robinson C, Hunter K, Dobrzanski P, Jones-Bolin S, Pritchard S, Aimone L, Klein-Szanto A, Herbert JM, Bono F, Schaeffer P, Casellas P, Bourie B, Pili R, Isaacs J, Ator M, Hudkins R, Vaught J, Mallamo J, Dionne C. CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models. Cancer Res. 2003 Sep 15;63(18):5978-91. Erratum in: Cancer Res. 2003 Nov 1;63(21):7543. PubMed
  • Miknyoczki SJ, Jones-Bolin S, Pritchard S, Hunter K, Zhao H, Wan W, Ator M, Bihovsky R, Hudkins R, Chatterjee S, Klein-Szanto A, Dionne C, Ruggeri B. Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. Mol Cancer Ther. 2003 Apr;2(4):371-82. PubMed
  • Bassi DE, Mahloogi H, Lopez De Cicco R, Klein-Szanto A. Increased furin activity enhances the malignant phenotype of human head and neck cancer cells. Am J Pathol. 2003 Feb;162(2):439-47. PubMed
    • Ozols RF, Daly MB, Klein-Szanto A, Hamilton TC, Bast RC Jr, Brewer MA. Specific keynote: chemoprevention of ovarian cancer: the journey begins. Gynecol Oncol. 2003 Jan;88(1 Pt 2):S59-66; discussion S67-70. Review. PubMed
  • L�pez de Cicco R, Bassi DE, Page R, Klein-Szanto AJ. Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology. Acta Odontol Latinoam. 2002;15(1-2):29-37. PubMed
  • Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK, Testa JR. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. 2004 Jul 29;23(34):5853-7. PubMed
  • Altomare DA, Tanno S, De Rienzo A, Klein-Szanto AJ, Tanno S, Skele KL, Hoffman JP, Testa JR. Frequent activation of AKT2 kinase in human pancreatic carcinomas. J Cell Biochem. 2002;87(4):470-6. Erratum in: J Cell Biochem. 2003 Jan 1;88(1):470. PubMed
  • Mahloogi H, Gonz�lez-Guerrico AM, Lopez De Cicco R, Bassi DE, Goodrow T, Braunewell KH, Klein-Szanto AJ. Overexpression of the calcium sensor visinin-like protein-1 leads to a cAMP-mediated decrease of in vivo and in vitro growth and invasiveness of squamous cell carcinoma cells. Cancer Res. 2003 Aug 15;63(16):4997-5004. PubMed
  • Mercapide J, Lopez De Cicco R, Castresana JS, Klein-Szanto AJ. Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. Int J Cancer. 2003 Sep 20;106(5):676-82. PubMed
  • Whitehead CM, Earle KA, Fetter J, Xu S, Hartman T, Chan DC, Zhao TL, Piazza G, Klein-Szanto AJ, Pamukcu R, Alila H, Bunn PA Jr, Thompson WJ. Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival. Mol Cancer Ther. 2003 May;2(5):479-88. PubMed
  • Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W, Donowitz M, Tsichlis PN, Larue L. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res. 2003 May 1;63(9):2172-8. PubMed
  • Mercapide J, Zhang SY, Fan X, Furi�-Bacete V, Schneider J, L�pez de la Osa I, Patchefsky AS, Klein-Szanto AJ, Castresana JS. CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast. Mol Carcinog. 2002 Sep;35(1):6-12. PubMed
  • Liu SC, Bassi DE, Zhang SY, Holoran D, Conti CJ, Klein-Szanto AJ. Overexpression of cyclin D2 is associated with increased in vivo invasiveness of human squamous carcinoma cells. Mol Carcinog. 2002 Jul;34(3):131-9. PubMed
  • Fedele M, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, Parlow AF, Visone R, Pierantoni GM, Outwater E, Santoro M, Croce CM, Fusco A. Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Oncogene. 2002 May 9;21(20):3190-8. PubMed
  • Mercapide J, Lopez De Cicco R, Bassi DE, Castresana JS, Thomas G, Klein-Szanto AJ. Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness. Clin Cancer Res. 2002 Jun;8(6):1740-6. PubMed
  • Mahloogi H, Bassi DE, Klein-Szanto AJ. Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4. Carcinogenesis. 2002 Apr;23(4):565-72. PubMed
  • Klein WM, Hruban RH, Klein-Szanto AJ, Wilentz RE. Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. Mod Pathol. 2002 Apr;15(4):441-7. PubMed
  • Bassi DE, Mahloogi H, Al-Saleem L, Lopez De Cicco R, Ridge JA, Klein-Szanto AJ. Elevated furin expression in aggressive human head and neck tumors and tumor cell lines. Mol Carcinog. 2001 Aug;31(4):224-32. PubMed
  • Bassi DE, Lopez De Cicco R, Mahloogi H, Zucker S, Thomas G, Klein-Szanto AJ. Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10326-31. Epub 2001 Aug 21. PubMed
  • Baldassarre G, Fedele M, Battista S, Vecchione A, Klein-Szanto AJ, Santoro M, Waldmann TA, Azimi N, Croce CM, Fusco A. Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7970-5. Epub 2001 Jun 26. PubMed
  • Piazza GA, Thompson WJ, Pamukcu R, Alila HW, Whitehead CM, Liu L, Fetter JR, Gresh WE Jr, Klein-Szanto AJ, Farnell DR, Eto I, Grubbs CJ. Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. Cancer Res. 2001 May 15;61(10):3961-8. PubMed
  • Liu SC, Zhang SY, Babb JS, Ridge JA, Klein-Szanto AJ. Image cytometry of cyclin D1: a prognostic marker for head and neck squamous cell carcinomas. Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):455-9. PubMed
  • Amuthan G, Biswas G, Zhang SY, Klein-Szanto A, Vijayasarathy C, Avadhani NG. Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J. 2001 Apr 17;20(8):1910-20. PubMed
  • Virmani J, Johnson EN, Klein-Szanto AJ, Funk CD. Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis. Cancer Lett. 2001 Jan 26;162(2):161-5. PubMed
  • Lee K, Klein-Szanto AJ, Kruh GD. Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells. J Natl Cancer Inst. 2000 Dec 6;92(23):1934-40. PubMed
  • Zhang SY, Liu SC, Johnson DG, Klein-Szanto AJ. E2F-1 gene transfer enhances invasiveness of human head and neck carcinoma cell lines. Cancer Res. 2000 Nov 1;60(21):5972-6. PubMed
  • Young NA, Ehya H, Klein-Szanto A, Litwin S, Smith MR, al-Saleem T. Differentiating large cell lymphoma from indolent small B-cell lymphoma in fine needle aspirates using p53, PCNA and transformed lymphocyte count. Acta Cytol. 2000 Jul-Aug;44(4):592-603. PubMed
  • Bassi DE, Mahloogi H, Klein-Szanto AJ. The proprotein convertases furin and PACE4 play a significant role in tumor progression. Mol Carcinog. 2000 Jun;28(2):63-9. Review. PubMed
  • Joseph P, Long DJ 2nd, Klein-Szanto AJ, Jaiswal AK. Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. Biochem Pharmacol. 2000 Jul 15;60(2):207-14. PubMed
  • Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK. Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer. 2000 May 1;88(9):2154-63. PubMed
  • Zhang SY, Liu SC, Al-Saleem LF, Holloran D, Babb J, Guo X, Klein-Szanto AJ. E2F-1: a proliferative marker of breast neoplasia. Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):395-401. PubMed
  • Liu SC, Klein-Szanto AJ. Markers of proliferation in normal and leukoplakic oral epithelia. Oral Oncol. 2000 Mar;36(2):145-51. Review. PubMed
Top

1990 - 1999

  • Sauter ER, Ehya H, Babb J, Diamandis E, Daly M, Klein-Szanto A, Sigurdson E, Hoffman J, Malick J, Engstrom PF. Biological markers of risk in nipple aspirate fluid are associated with residual cancer and tumour size. Br J Cancer. 1999 Dec;81(7):1222-7. PubMed
  • Riccio A, Aaltonen LA, Godwin AK, Loukola A, Percesepe A, Salovaara R, Masciullo V, Genuardi M, Paravatou-Petsotas M, Bassi DE, Ruggeri BA, Klein-Szanto AJ, Testa JR, Neri G, Bellacosa A. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet. 1999 Nov;23(3):266-8. PubMed
  • Sauter ER, Nesbit M, Litwin S, Klein-Szanto AJ, Cheffetz S, Herlyn M. Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas. Cancer Res. 1999 Oct 1;59(19):4876-81. PubMed
  • Battista S, Fidanza V, Fedele M, Klein-Szanto AJ, Outwater E, Brunner H, Santoro M, Croce CM, Fusco A. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res. 1999 Oct 1;59(19):4793-7. PubMed
  • Miknyoczki SJ, Chang H, Klein-Szanto A, Dionne CA, Ruggeri BA. The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma. Clin Cancer Res. 1999 Aug;5(8):2205-12. PubMed
  • Miknyoczki SJ, Dionne CA, Klein-Szanto AJ, Ruggeri BA. The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness. Ann N Y Acad Sci. 1999 Jun 30;880:252-62. PubMed
  • Miknyoczki SJ, Lang D, Huang L, Klein-Szanto AJ, Dionne CA, Ruggeri BA. Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int J Cancer. 1999 May 5;81(3):417-27. PubMed
  • Plank TL, Logginidou H, Klein-Szanto A, Henske EP. The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas. Mod Pathol. 1999 May;12(5):539-45. PubMed
  • Liu SC, Hu Y, Sauter ER, Clapper ML, Chen SY, Lanfranchi HE, Engstrom PF, Klein-Szanto AJ. Image analysis of p53 and cyclin D1 expression in premalignant lesions of the oral mucosa. Anal Quant Cytol Histol. 1999 Apr;21(2):166-73. PubMed
  • Sauter ER, Nesbit M, Watson JC, Klein-Szanto A, Litwin S, Herlyn M. Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res. 1999 Apr;5(4):775-82. PubMed
  • Gude RP, Binda MM, Presas HL, Klein-Szanto AJ, Bonfil RD. Studies on the mechanisms responsible for inhibition of experimental metastasis of B16-F10 murine melanoma by pentoxifylline. J Biomed Sci. 1999 Mar-Apr;6(2):133-41. PubMed
  • Sauter ER, Klein-Szanto AJ, Atillasoy E, Montone KT, Goodrow T, Binder RL, Seykora JT, Herlyn M. Ultraviolet B-induced squamous epithelial and melanocytic cell changes in a xenograft model of cancer development in human skin. Mol Carcinog. 1998 Nov;23(3):168-74. PubMed
  • Ma J, Fei ZL, Klein-Szanto A, Gallo JM. Modulation of angiogenesis by human glioma xenograft models that differentially express vascular endothelial growth factor. Clin Exp Metastasis. 1998 Aug;16(6):559-68. PubMed
  • Joseph P, Klein-Szanto AJ, Jaiswal AK. Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis. Br J Cancer. 1998 Aug;78(3):312-20. PubMed
  • Zhang S, Guo, Klein-Szanto A. [p53 gene mutations in mouse skin tumors induced by DMBA-TPA-MNNG]. Zhonghua Bing Li Xue Za Zhi. 1998 Aug;27(4):298-300. Chinese. PubMed
  • Lifsted T, Le Voyer T, Williams M, Muller W, Klein-Szanto A, Buetow KH, Hunter KW. Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer. 1998 Aug 12;77(4):640-4. PubMed
  • Liu SC, Sauter ER, Clapper ML, Feldman RS, Levin L, Chen SY, Yen TJ, Ross E, Engstrom PF, Klein-Szanto AJ. Markers of cell proliferation in normal epithelia and dysplastic leukoplakias of the oral cavity. Cancer Epidemiol Biomarkers Prev. 1998 Jul;7(7):597-603. PubMed
  • Kisielewski AE, Xiao GH, Liu SC, Klein-Szanto AJ, Novara M, Sina J, Bleicher K, Yeung RS, Goodrow TL. Analysis of the FHIT gene and its product in squamous cell carcinomas of the head and neck. Oncogene. 1998 Jul 9;17(1):83-91. PubMed
  • Tanno S, Obara T, Fujii T, Mizukami Y, Shudo R, Nishino N, Ura H, Klein-Szanto AJ, Kohgo Y. Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union. Cancer. 1998 Jul 15;83(2):267-75. PubMed
  • Law SF, Zhang YZ, Klein-Szanto AJ, Golemis EA. Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. Mol Cell Biol. 1998 Jun;18(6):3540-51. PubMed
  • Radjendirane V, Joseph P, Lee YH, Kimura S, Klein-Szanto AJ, Gonzalez FJ, Jaiswal AK. Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem. 1998 Mar 27;273(13):7382-9. PubMed
  • Henske EP, Wessner LL, Golden J, Scheithauer BW, Vortmeyer AO, Zhuang Z, Klein-Szanto AJ, Kwiatkowski DJ, Yeung RS. Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am J Pathol. 1997 Dec;151(6):1639-47. PubMed
  • Xiao GH, Jin F, Klein-Szanto AJ, Goodrow TL, Linehan MW, Yeung RS. The FHIT gene product is highly expressed in the cytoplasm of renal tubular epithelium and is down-regulated in kidney cancers. Am J Pathol. 1997 Dec;151(6):1541-7. PubMed
  • Hubbard FC, Goodrow TL, Liu SC, Brilliant MH, Basset P, Mains RE, Klein-Szanto AJ. Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability. Cancer Res. 1997 Dec 1;57(23):5226-31. PubMed
  • Yeung RS, Katsetos CD, Klein-Szanto A. Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis. Am J Pathol. 1997 Nov;151(5):1477-86. PubMed
  • Smith MK, Goral MA, Wright JH, Matrisian LM, Morris RJ, Klein-Szanto AJ, Gilmour SK. Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness. Cancer Res. 1997 Jun 1;57(11):2104-8. PubMed
  • Zhang SY, Liu SC, Goodrow T, Morris R, Klein-Szanto AJ. Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms. Mol Carcinog. 1997 Mar;18(3):142-52. PubMed
  • Ruggeri BA, Huang L, Berger D, Chang H, Klein-Szanto AJ, Goodrow T, Wood M, Obara T, Heath CW, Lynch H. Molecular pathology of primary and metastatic ductal pancreatic lesions: analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesions. Cancer. 1997 Feb 15;79(4):700-16. PubMed
  • Mitsunaga S, Clapper M, Litwin S, Watts P, Bauer B, Klein-Szanto AJ. Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene. J Cell Biochem Suppl. 1997;28-29:81-9. PubMed
  • Sauter ER, Ross E, Daly M, Klein-Szanto A, Engstrom PF, Sorling A, Malick J, Ehya H. Nipple aspirate fluid: a promising non-invasive method to identify cellular markers of breast cancer risk. Br J Cancer. 1997;76(4):494-501. PubMed
  • Medcalf AS, Klein-Szanto AJ, Cristofalo VJ. Expression of p21 is not required for senescence of human fibroblasts. Cancer Res. 1996 Oct 15;56(20):4582-5. PubMed
  • Taguchi T, Zhou JY, Feder M, Litwin S, Klein-Szanto AJ, Testa JR. Detection of aneuploidy in interphase nuclei from non-small cell lung carcinomas by fluorescence in situ hybridization using chromosome-specific repetitive DNA probes. Cancer Genet Cytogenet. 1996 Jul 15;89(2):120-5. PubMed
  • Devineni D, Klein-Szanto A, Gallo JM. Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470. Cancer Res. 1996 May 1;56(9):1983-7. PubMed
  • Huang L, Goodrow TL, Zhang SY, Klein-Szanto AJ, Chang H, Ruggeri BA. Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas. Cancer Res. 1996 Mar 1;56(5):1137-41. PubMed
  • Huang L, Lang D, Geradts J, Obara T, Klein-Szanto AJ, Lynch HT, Ruggeri BA. Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines. Mol Carcinog. 1996 Feb;15(2):85-95. PubMed
  • Miknyoczki SJ, Klein-Szanto AJ, Ruggeri BA. Neurotrophin-Trk receptor interactions in neoplasia: a possible role in interstitial and perineural invasion in ductal pancreatic cancer. Crit Rev Oncog. 1996;7(1-2):89-100. Review. PubMed
  • Devineni D, Klein-Szanto A, Gallo JM. In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-bearing rats. Cancer Chemother Pharmacol. 1996;38(6):499-507. PubMed
  • Peralta Soler A, Knudsen KA, Jaurand MC, Johnson KR, Wheelock MJ, Klein-Szanto AJ, Salazar H. The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. Hum Pathol. 1995 Dec;26(12):1363-9. PubMed
  • Bianchi AB, Mitsunaga SI, Cheng JQ, Klein WM, Jhanwar SC, Seizinger B, Kley N, Klein-Szanto AJ, Testa JR. High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10854-8. PubMed
  • Sirotkin AM, Edelmann W, Cheng G, Klein-Szanto A, Kucherlapati R, Skoultchi AI. Mice develop normally without the H1(0) linker histone. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6434-8. PubMed
  • Mitsunaga SI, Zhang SY, Ruggeri BA, Gimenez-Conti I, Robles AI, Conti CJ, Klein-Szanto AJ. Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene. Carcinogenesis. 1995 Jul;16(7):1629-35. PubMed
  • Sauter ER, Ridge JA, Trock B, Cleveland D, Whitley KV, Mohr RM, Klein-Szanto A. Overexpression of the p53 gene in primary and metastatic head and neck carcinomas. Laryngoscope. 1995 Jun;105(6):653-6. PubMed
  • Zenklusen JC, Thompson JC, Klein-Szanto AJ, Conti CJ. Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: evidence for a broad range tumor suppressor gene. Cancer Res. 1995 Mar 15;55(6):1347-50. PubMed
  • Zhang SY, Bauer B, Mitsunaga S, Goodrow TL, Klein-Szanto AJ. Lack of concordant p53 mutations in some paired primary and metastatic mouse squamous cell carcinomas induced by chemical carcinogenesis. Mol Carcinog. 1995 Feb;12(2):77-81. PubMed
  • Devineni D, Klein-Szanto A, Gallo JM. Tissue distribution of methotrexate following administration as a solution and as a magnetic microsphere conjugate in rats bearing brain tumors. J Neurooncol. 1995;24(2):143-52. PubMed
  • Zhang SY, Caamano J, Cooper F, Guo X, Klein-Szanto AJ. Immunohistochemistry of cyclin D1 in human breast cancer. Am J Clin Pathol. 1994 Nov;102(5):695-8. PubMed
  • 96: Sauter ER, Cleveland D, Trock B, Ridge JA, Klein-Szanto AJ. p53 is overexpressed in fifty percent of pre-invasive lesions of head and neck epithelium. Carcinogenesis. 1994 Oct;15(10):2269-74. PubMed
  • Zhang SY, Klein-Szanto AJ, Sauter ER, Shafarenko M, Mitsunaga S, Nobori T, Carson DA, Ridge JA, Goodrow TL. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res. 1994 Oct 1;54(19):5050-3. PubMed
  • Klein-Szanto AJ, Silvers WK, Mintz B. Ultraviolet radiation-induced malignant skin melanoma in melanoma-susceptible transgenic mice. Cancer Res. 1994 Sep 1;54(17):4569-72. PubMed
  • Gwin JL, Klein-Szanto AJ, Zhang SY, Agarwal P, Rogatko A, Keller SM. Loss of blood group antigen A in non-small cell lung cancer. Ann Surg Oncol. 1994 Sep;1(5):423-7. PubMed
  • Ruggeri BA, Bauer B, Zhang SY, Klein-Szanto AJ. Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities. Carcinogenesis. 1994 Aug;15(8):1613-9. PubMed
  • Patamalai B, Burow DL, Gimenez-Conti I, Zenklusen JC, Conti CJ, Klein-Szanto AJ, Fischer SM. Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis. Mol Carcinog. 1994 Apr;9(4):220-9. PubMed
  • Zhang SY, Ruggeri B, Agarwal P, Sorling AF, Obara T, Ura H, Namiki M, Klein-Szanto AJ. Immunohistochemical analysis of p53 expression in human pancreatic carcinomas. Arch Pathol Lab Med. 1994 Feb;118(2):150-4. PubMed
  • Bianchi AB, Hara T, Ramesh V, Gao J, Klein-Szanto AJ, Morin F, Menon AG, Trofatter JA, Gusella JF, Seizinger BR, et al. Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat Genet. 1994 Feb;6(2):185-92. PubMed
  • Mintz B, Silvers WK, Klein-Szanto AJ. Histopathogenesis of malignant skin melanoma induced in genetically susceptible transgenic mice. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8822-6. PubMed
  • Iizasa T, Momiki S, Bauer B, Caamano J, Metcalf R, Lechner J, Harris CC, Klein-Szanto AJ. Invasive tumors derived from xenotransplanted, immortalized human cells after in vivo exposure to chemical carcinogens. Carcinogenesis. 1993 Sep;14(9):1789-94. PubMed
  • Caamano J, Zhang SY, Rosvold EA, Bauer B, Klein-Szanto AJ. p53 alterations in human squamous cell carcinomas and carcinoma cell lines. Am J Pathol. 1993 Apr;142(4):1131-9. PubMed
  • Ruggeri B, DiRado M, Zhang SY, Bauer B, Goodrow T, Klein-Szanto AJ. Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1013-7. PubMed
  • Itoiz ME, Larcher F, Lanfranchi HE, Diaz J, Klein-Szanto AJ, Conti CJ. Simultaneous PAGE, immunoblotting, and immunohistochemical analysis of differentiation associated keratins in lesions of the oral mucosa. Acta Odontol Latinoam. 1993;7(2):13-22. PubMed
  • Hino O, Klein-Szanto AJ, Freed JJ, Testa JR, Brown DQ, Vilensky M, Yeung RS, Tartof KD, Knudson AG. Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):327-31. PubMed
  • Klein-Szanto AJ, Ruggeri B, Bianchi A, Conti CJ. Cellular and molecular changes during mouse skin tumor progression. Recent Results Cancer Res. 1993;128:193-204. Review. PubMed
  • Garcia de Palazzo I, Klein-Szanto A, Weiner LM. Immunohistochemical detection of c-erbB-2 expression by neoplastic human tissue using monospecific and bispecific monoclonal antibodies. Int J Biol Markers. PubMed
  • Mintz B, Klein-Szanto AJ. Malignancy of eye melanomas originating in the retinal pigment epithelium of transgenic mice after genetic ablation of choroidal melanocytes. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11421-5. PubMed
  • Zucker S, Lysik RM, Malik M, Bauer BA, Caamano J, Klein-Szanto AJ. Secretion of gelatinases and tissue inhibitors of metalloproteinases by human lung cancer cell lines and revertant cell lines: not an invariant correlation with metastasis. Int J Cancer. 1992 Sep 30;52(3):366-71. PubMed
  • Eisenberg BL, Lanciano RM, Nussbaum ML, Klein-Szanto A, Taylor DD. Intraoperative liver radiation after partial hepatectomy in a rat model. J Surg Res. 1992 Sep;53(3):287-92. PubMed
  • Ruggeri B, Zhang SY, Caamano J, DiRado M, Flynn SD, Klein-Szanto AJ. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene. 1992 Aug;7(8):1503-11. PubMed
  • Klein-Szanto AJ, Iizasa T, Momiki S, Garcia-Palazzo I, Caamano J, Metcalf R, Welsh J, Harris CC. A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6693-7. PubMed
  • Klein-Szanto AJ, Ura H, Momiki S, Bonfil D, Litwin S. Effects of formaldehyde on xenotransplanted human respiratory epithelium. Res Rep Health Eff Inst. 1992 Jul;(51):1-17; discussion 19-27. PubMed
  • Ruggeri B, Caamano J, Slaga TJ, Conti CJ, Nelson WJ, Klein-Szanto AJ. Alterations in the expression of uvomorulin and Na+,K(+)-adenosine triphosphatase during mouse skin tumor progression. Am J Pathol. 1992 May;140(5):1179-85. PubMed
  • Klein-Szanto AJ. Carcinogenic effects of chemotherapeutic compounds. Prog Clin Biol Res. 1992;374:167-74. Review. PubMed
  • Conti CJ, Bianchi AB, Navone NM, Ruggieri BA, Caamano J, Goodrow T, Klein-Szanto AJ. Tumor suppressor genes in squamous cell carcinoma. Prog Clin Biol Res. 1992;376:85-101. Review. PubMed
  • Caamano J, Ruggeri BA, Klein-Szanto AJ. A catalog of p53 alterations in selected human and laboratory animal neoplasms. Prog Clin Biol Res. 1992;376:331-55. Review. PubMed
  • Ruggeri B, Zhang SY, Klein-Szanto AJ. Molecular and cytogenetic alterations in human pancreatic cancer: the role of tumor suppressor genes. Prog Clin Biol Res. 1992;376:245-60. Review. PubMed
  • Caamano J, DiRado M, Iizasa T, Momiki S, Fernandes E, Ashendel C, Noda M, Klein-Szanto AJ. Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1. Mol Carcinog. 1992;6(4):252-9. PubMed
  • Ruggeri B, Caamano J, Goodrow T, DiRado M, Bianchi A, Trono D, Conti CJ, Klein-Szanto AJ. Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res. 1991 Dec 15;51(24):6615-21. PubMed
  • Caamano J, Ruggeri B, Momiki S, Sickler A, Zhang SY, Klein-Szanto AJ. Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines. Am J Pathol. 1991 Oct;139(4):839-45. PubMed
  • Buchmann A, Ruggeri B, Klein-Szanto AJ, Balmain A. Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7. Cancer Res. 1991 Aug 1;51(15):4097-101. PubMed
  • Pfeifer AM, Jones RT, Bowden PE, Mann D, Spillare E, Klein-Szanto AJ, Trump BF, Harris CC. Human bronchial epithelial cells transformed by the c-raf-1 and c-myc protooncogenes induce multidifferentiated carcinomas in nude mice: a model for lung carcinogenesis. Cancer Res. 1991 Jul 15;51(14):3793-801. PubMed
  • Klein-Szanto A, Bradl M, Porter S, Mintz B. Melanosis and associated tumors in transgenic mice. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):169-73. PubMed
  • Bradl M, Klein-Szanto A, Porter S, Mintz B. Malignant melanoma in transgenic mice. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):164-8. PubMed
  • Basolo F, Elliott J, Tait L, Chen XQ, Maloney T, Russo IH, Pauley R, Momiki S, Caamano J, Klein-Szanto AJ, et al. Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol Carcinog. 1991;4(1):25-35. PubMed
  • Klein-Szanto AJ. The role of chemically induced epithelial hyperplasia in the development of human cancer. Prog Clin Biol Res. 1991;369:35-41. Review. PubMed
  • Chiba M, Aldaz CM, Conti CJ, Klein-Szanto AJ. Metastatic potential of mouse skin carcinomas produced by different protocols of chemical carcinogenesis. Invasion Metastasis. 1991;11(5):288-96. PubMed
  • Momiki S, Baba M, Caamano J, Iizasa T, Nakajima M, Yamaguchi Y, Klein-Szanto A. In vivo and in vitro invasiveness of human lung carcinoma cell lines. Invasion Metastasis. 1991;11(2):66-75. PubMed
  • Morris RJ, Fischer SM, Klein-Szanto AJ, Slaga TJ. Subpopulations of primary adult murine epidermal basal cells sedimented on density gradients. Cell Tissue Kinet. 1990 Nov;23(6):587-602. PubMed
  • Lazo PA, Klein-Szanto AJ, Tsichlis PN. T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications. J Virol. 1990 Aug;64(8):3948-59. PubMed
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1980 - 1989

  • Bonfil RD, Momiki S, Fridman R, Reich R, Reddel R, Harris CC, Klein-Szanto A. Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by 12-O-tetradecanoyl-phorbol-13-acetate and diacylglycerol. Carcinogenesis. 1989 Dec;10(12):2335-8. PubMed
  • Klein-Szanto AJ, Larcher F, Bonfil RD, Conti CJ. Multistage chemical carcinogenesis protocols produce spindle cell carcinomas of the mouse skin. Carcinogenesis. 1989 Nov;10(11):2169-72. PubMed
  • Ura H, Bonfil RD, Reich R, Reddel R, Pfeifer A, Harris CC, Klein-Szanto AJ. Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells. Cancer Res. 1989 Aug 15;49(16):4615-21. PubMed
  • Bonfil RD, Momiki S, Conti CJ, Klein-Szanto AJ. Benzoyl peroxide enhances the invasive ability of a mouse epidermal carcinoma cell line. Int J Cancer. 1989 Jul 15;44(1):165-9. PubMed
  • Ura H, Nowak P, Litwin S, Watts P, Bonfil RD, Klein-Szanto AJ. Effects of formaldehyde on normal xenotransplanted human tracheobronchial epithelium. Am J Pathol. 1989 Jan;134(1):99-106. PubMed
  • Klein-Szanto AJ, Ura H, Resau J. Formaldehyde-induced lesions of xenotransplanted human nasal respiratory epithelium. Toxicol Pathol. 1989;17(1 Pt 1):33-7. PubMed
  • Klein-Szanto AJ. Morphological evaluation of the effects of carcinogens and promoters. Prog Clin Biol Res. 1989;298:45-62. Review. PubMed
  • Klein-Szanto AJ. Pathology of human and experimental skin tumors. Carcinog Compr Surv. 1989;11:19-53. Review. PubMed
  • Baba M, Obara T, Bonfil RD, Yamaguchi Y, Trump BF, Resau J, Klein-Szanto AJ. Resistance to serum-induced terminal differentiation in normal human tracheobronchial epithelial cells after in vivo exposure to 7,12-dimethylbenz[a]anthracene. Jpn J Cancer Res. 1988 Jun;79(6):734-41. PubMed
  • Obara T, Baba M, Yamaguchi Y, Fuchs E, Resau JH, Trump BF, Klein-Szanto AJ. Localization of keratin mRNA in human tracheobronchial epithelium and bronchogenic carcinomas by in situ hybridization. Am J Pathol. 1988 Jun;131(3):519-29. PubMed
  • Klein-Szanto AJ, Boysen M, Reith A. Keratin and involucrin in preneoplastic and neoplastic lesions. Distribution in the nasal mucosa of nickel workers. Arch Pathol Lab Med. 1987 Nov;111(11):1057-61. PubMed
  • Aldaz CM, Conti CJ, Klein-Szanto AJ, Slaga TJ. Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proc Natl Acad Sci U S A. 1987 Apr;84(7):2029-32. PubMed
  • Patskan GJ, Klein-Szanto AJ, Phillips JL, Slaga TJ. Metastasis from squamous cell carcinomas of SENCAR mouse skin produced by complete carcinogenesis. Cancer Lett. 1987 Feb;34(2):121-7. PubMed
  • Baba M, Klein-Szanto AJ, Trono D, Obara T, Yoakum GH, Masui T, Harris CC. Preneoplastic and neoplastic growth of xenotransplanted lung-derived human cell lines using deepithelialized rat tracheas. Cancer Res. 1987 Jan 15;47(2):573-8. PubMed
  • Shiba M, Marchok AC, Klein-Szanto AJ, Yamaguchi Y. Pathological changes induced by formaldehyde in open-ended rat tracheal implants preexposed to benzo(a)pyrene. Toxicol Pathol. 1987;15(4):401-8. PubMed
  • Conti CJ, Aldaz CM, O'Connell J, Klein-Szanto AJ, Slaga TJ. Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis. 1986 Nov;7(11):1845-8. PubMed
  • Fernández Alonso GI, Obara T, Klein-Szanto AJ, Conti CJ. Antibodies reacting against cytoskeletal proteins in Waldenstrom's disease. Allergol Immunopathol (Madr). 1986 Nov-Dec;14(6):467-72. PubMed
  • Klein-Szanto AJ, Conti CJ, Aldaz CM, Clapp N, Nesnow S, Slaga TJ. Effects of chronic topical application of 12-O-tetradecanoylphorbol-13-acetate on the skin and internal organs of SENCAR mice. Environ Health Perspect. 1986 Sep;68:75-80. PubMed
  • Conti CJ, Fries JW, Aldaz CM, Klein-Szanto AJ, Slaga TJ. Allogeneic transplantation of normal epidermal cells and squamous cell carcinomas in SENCAR mice. Environ Health Perspect. 1986 Sep;68:125-9. PubMed
  • Kehrer JP, Klein-Szanto AJ, Thurston DE, Lindenschmidt RC, Witschi HR. O,S,S,-trimethyl phosphorodithioate-induced lung damage in rats and mice. Toxicol Appl Pharmacol. 1986 Jul;84(3):480-92. PubMed
  • Aldaz CM, Conti CJ, O'Connell J, Yuspa SH, Klein-Szanto AJ, Slaga TJ. Cytogenetic evidence for gene amplification in mouse skin carcinogenesis. Cancer Res. 1986 Jul;46(7):3565-8. PubMed
  • O'Connell JF, Klein-Szanto AJ, DiGiovanni DM, Fries JW, Slaga TJ. Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide. Cancer Res. 1986 Jun;46(6):2863-5. PubMed
  • Klein-Szanto AJ, Baba M, Trono D, Obara T, Resau J, Trump BF. Epidermoid metaplasias of xenotransplanted human tracheobronchial epithelium. Carcinogenesis. 1986 Jun;7(6):987-94. PubMed
  • Itoiz ME, Conti CJ, Gimenez IB, Lanfranchi HE, Fernandez-Alonso GI, Klein-Szanto AJ. Immunodetection of involucrin in lesions of the oral mucosa. J Oral Pathol. 1986 Apr;15(4):205-8. PubMed
  • Obara T, Conti CJ, Baba M, Resau JH, Trifillis AL, Trump BF, Klein-Szanto AJ. Rapid detection of xenotransplanted human tissues using in situ hybridization. Am J Pathol. 1986 Mar;122(3):386-91. PubMed
  • O'Connell JF, Klein-Szanto AJ, Digiovanni DM, Fries JW, Slaga TJ. Malignant progression of mouse skin papillomas treated with ethylnitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine, or 12-O-tetradecanoylphorbol-13-acetate. Cancer Lett. 1986 Mar;30(3):269-74. PubMed
  • Aldaz CM, Conti CJ, Klein-Szanto AJ, Slaga TJ. A direct cytogenetic technique for mouse skin carcinomas and papillomas. Cancer Genet Cytogenet. 1986 Feb 15;20(3-4):223-9. PubMed
  • Chiba M, Maley MA, Klein-Szanto AJ. Sequential study of gamma-glutamyltransferase during complete and two-stage mouse skin carcinogenesis. Cancer Res. 1986 Jan;46(1):259-63. PubMed
  • Conti CJ, Clapp N, Klein-Szanto AJ, Nesnow S, Slaga TJ. Survival curves and incidence of neoplastic and non-neoplastic disease in SENCAR mice. Carcinogenesis. 1985 Nov;6(11):1649-52. PubMed
  • Kehrer JP, Klein-Szanto AJ. Enhanced acute lung damage in mice following administration of 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 1985 Nov;45(11 Pt 2):5707-13. PubMed
  • Fischer SM, Hardin L, Klein-Szanto A, Slaga TJ. Retinoyl-phorbol-acetate is a complete skin tumor promoter in SENCAR mice. Cancer Lett. 1985 Jul;27(3):323-7. PubMed
  • Itoiz ME, Conti CJ, Lanfranchi HE, Mamrack M, Klein-Szanto AJ. Immunohistochemical detection of filaggrin in preneoplastic and neoplastic lesions of the human oral mucosa. Am J Pathol. 1985 Jun;119(3):456-61. PubMed
  • Aldaz CM, Conti CJ, Gimenez IB, Slaga TJ, Klein-Szanto AJ. Cutaneous changes during prolonged application of 12-O-tetradecanoylphorbol-13-acetate on mouse skin and residual effects after cessation of treatment. Cancer Res. 1985 Jun;45(6):2753-9. PubMed
  • Fischer SM, Klein-Szanto AJ, Adams LM, Slaga TJ. The first stage and complete promoting activity of retinoic acid but not the analog RO-10-9359. Carcinogenesis. 1985 Apr;6(4):575-8. PubMed
  • Klein-Szanto AJ. Distribution of keratins and involucrin in human fetal oral epithelia. Acta Odontol Latinoam. 1985;2(2):35-41. PubMed
  • Chiba M, Taylor CM, Klein-Szanto AJ. Comparison of differentiation patterns in 12-O-tetradecanoylphorbol-13-acetate-treated epidermis and fetal epidermis. Arch Dermatol Res. 1985;277(6):457-65. PubMed
  • Klein-Szanto AJ, Marchok AC, Terzaghi M. In vivo studies on enhancement and promotion of respiratory tract carcinogenesis: studies with heterotopic tracheal transplants. Carcinog Compr Surv. 1985;8:119-30. PubMed
  • Klein-Szanto AJ, Chiba M, Lee SU, Conti CJ, Thetford D. Keratinocyte damage produced by 12-O-tetradecanoylphorbol-13-acetate in rodent epidermis. Carcinogenesis. 1984 Nov;5(11):1459-65. PubMed
  • Klein-Szanto AJ, Barr RJ, Reiners JJ Jr, Mamrack MD. Filaggrin distribution in keratoacanthomas and squamous cell carcinoma. Arch Pathol Lab Med. 1984 Nov;108(11):888-90. PubMed
  • Kehrer JP, Klein-Szanto AJ, Sorensen EM, Pearlman R, Rosner MH. Enhanced acute lung damage following corticosteroid treatment. Am Rev Respir Dis. 1984 Aug;130(2):256-61. PubMed
  • Mamrack MD, Klein-Szanto AJ, Reiners JJ Jr, Slaga TJ. Alteration in the distribution of the epidermal protein filaggrin during two-stage chemical carcinogenesis in the SENCAR mouse skin. Cancer Res. 1984 Jun;44(6):2634-41. PubMed
  • Klein-Szanto AJ, Pal BC, Terzaghi M, Marchok AC. Heterotopic tracheal transplants: techniques and applications. Environ Health Perspect. 1984 Jun;56:75-86. Review. PubMed
  • Chiba M, Slaga TJ, Klein-Szanto AJ. A morphometric study of dedifferentiated and involutional dark keratinocytes in 12-O-tetradecanoylphorbol-13-acetate-treated mouse epidermis. Cancer Res. 1984 Jun;44(6):2711-7. PubMed
  • Shiba M, Marchok AC, Klein-Szanto AJ. The effects of formaldehyde gas in a flow-through rat tracheal implant system. Toxicology. 1984 Apr 16;30(4):317-25. PubMed
  • Shiba M, Ohiwa T, Klein-Szanto AJ. Lectin-binding sites in preneoplastic and neoplastic lesions of human and rodent respiratory tracts. J Natl Cancer Inst. 1984 Jan;72(1):43-51. PubMed
  • Shiba M, Marchok AC, Klein-Szanto AJ. An open-ended rat tracheal implant model: toxic effects of formaldehyde on the respiratory epithelium. Toxicol Lett. 1983 May;16(3-4):241-8. PubMed
  • Terzaghi M, Klein-Szanto A, Nettesheim P. Effect of the promoter 12-O-tetradecanoylphorbol-13-acetate on the evolution of carcinogen-altered cell populations in tracheas initiated with 7,12-dimethylbenz(a)anthracene. Cancer Res. 1983 Apr;43(4):1461-6. PubMed
  • Haschek WM, Reiser KM, Klein-Szanto AJ, Kehrer JP, Smith LH, Last JA, Witschi HP. Potentiation of butylated hydroxytoluene-induced acute lung damage by oxygen. Cell kinetics and collagen metabolism. Am Rev Respir Dis. 1983 Jan;127(1):28-34. PubMed
  • Slaga TJ, Klein-Szanto AJ. Initiation-promotion versus complete skin carcinogenesis in mice: importance of dark basal keratinocytes (stem cells). Cancer Invest. 1983;1(5):425-36. Review. PubMed
  • Klein-Szanto AJ, Nelson KG, Shah Y, Slaga TJ. Simultaneous appearance of keratin modifications and gamma-glutamyltransferase activity as indicators of tumor progression in mouse skin papillomas. J Natl Cancer Inst. 1983 Jan;70(1):161-8. PubMed
  • Shiba M, Klein-Szanto AJ. Variation of gamma glutamyl transpeptidase activity and lectin binding in the course of carcinogenesis of the respiratory tract epithelium. Carcinogenesis. 1983;4(6):687-91. PubMed
  • Shiba M, Klein-Szanto AJ, Marchok AC, Pal BC, Nettesheim P. Effect of carcinogen release rate on the incidence of preneoplastic and neoplastic lesions of the respiratory tract epithelium in rats. J Natl Cancer Inst. 1982 Nov;69(5):1155-61. PubMed
  • Klein-Szanto AJ, Terzaghi M, Mirkin LD, Martin D, Shiba M. Propagation of normal human epithelial cell populations using an in vivo culture system. Description and applications. Am J Pathol. 1982 Aug;108(2):231-9. PubMed
  • Klein-Szanto AJ, Slaga TJ. Effects of peroxides on rodent skin: epidermal hyperplasia and tumor promotion. J Invest Dermatol. 1982 Jul;79(1):30-4. PubMed
  • Klein-Szanto AJ, Nettesheim P, Saccomanno G. Dark epithelial cells in preneoplastic lesions of the human respiratory tract. Cancer. 1982 Jul 1;50(1):107-13. PubMed
  • Klein-Szanto AJ, Sega M, Banoczy J, Albrecht M. Dark cells in human oral leukoplakias. J Oral Pathol. 1982 Jun;11(3):228-36. PubMed
  • Haschek WM, Klein-Szanto AJ, Last JA, Reiser KM, Witschi H. Long-term morphologic and biochemical features of experimentally induced lung fibrosis in the mouse. Lab Invest. 1982 Apr;46(4):438-49. PubMed
  • Bourin MC, Delescluse C, Fürstenberger G, Marks F, Schweizer J, Klein-Szanto AJ, Prunieras M. Effect of phorbol esters on guniea pig skin in vivo. Carcinogenesis. 1982;3(6):671-6. PubMed
  • Slaga TJ, Fischer SM, Weeks CE, Klein-Szanto AJ, Reiners J. Studies on the mechanisms involved in multistage carcinogenesis in mouse skin. J Cell Biochem. 1982;18(1):99-119. Review. PubMed
  • Slaga TJ, Fischer SM, Weeks CE, Nelson K, Mamrack M, Klein-Szanto AJ. Specificity and mechanism(s) of promoter inhibitors in multistage promotion. Carcinog Compr Surv. 1982;7:19-34. Review. PubMed
  • Klein-Szanto AJ, Martin D, Sega M. Hyperkeratinization and hyperplasia of the forestomach epithelium in vitamin A deficient rats. Virchows Arch B Cell Pathol Incl Mol Pathol. 1982;40(3):387-94. PubMed
  • Klein-Szanto AJ, Major SK, Slaga TJ. Quantitative evaluation of dark keratinocytes induced by several promoting and hyperplasiogenic agents: their use as an early morphological indicator of tumor-promoting action. Carcinog Compr Surv. 1982;7:305-9. PubMed
  • Haschek WM, Brody AR, Klein-Szanto AJ, Witschi H. Animal model of human disease. Diffuse interstitial pulmonary fibrosis. Pulmonary fibrosis in mice induced by treatment with butylated hydroxytoluene and oxygen. Am J Pathol. 1981 Dec;105(3):333-5. PubMed
  • Klein-Szanto AJ, Slaga TJ. Numerical variation of dark cells in normal and chemically induced hyperplastic epidermis with age of animal and efficiency of tumor promoter. Cancer Res. 1981 Nov;41(11 Pt 1):4437-40. PubMed
  • Slaga TJ, Klein-Szanto AJ, Triplett LL, Yotti LP, Trosko KE. Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound. Science. 1981 Aug 28;213(4511):1023-5. PubMed
  • Marchok AC, Clark JN, Klein-Szanto A. Modulation of growth, differentiation, and mucous glycoprotein synthesis by retinyl acetate in cloned carcinoma cell lines. J Natl Cancer Inst. 1981 Jun;66(6):1165-74. PubMed
  • Klein-Szanto AJ, Nettesheim P, Pine A, Martin D. Distribution and ultrastructural characteristics of dark cells in squamous metaplasias of the respiratory tract epithelium. Am J Pathol. 1981 May;103(2):263-70. PubMed
  • de Rey BM, Lanfranchi HE, Klein-Szanto AJ, Itoiz ME. Effects of the hypoxic radiosensitizer misonidazole on normal and irradiated epidermis. J Cutan Pathol. 1981 Apr;8(2):89-95. PubMed
  • Marchok AC, Clark JN, Klein-Szanto A. Modulation of differentiation and mucous glycoprotein synthesis in cloned tracheal epithelial tumor cells exposed to retinyl acetate in vitro. Ann N Y Acad Sci. 1981 Feb 27;359:410-1. PubMed
  • Witschi HR, Haschek WM, Klein-Szanto AJ, Hakkinen PJ. Potentiation of diffuse lung damage by oxygen: determining variables. Am Rev Respir Dis. 1981 Jan;123(1):98-103. PubMed
  • Nettesheim P, Klein-Szanto AJ, Marchok AC, Steele VE, Terzaghi M, Topping DC. Studies of neoplastic development in respiratory tract epithelium. Arch Pathol Lab Med. 1981 Jan;105(1):1-10. PubMed
  • Terzaghi M, Klein-Szanto AJ. Differentiation of normal and cultured preneoplastic tracheal epithelial cells in rats: importance of epithelial mesenchymal interactions. J Natl Cancer Inst. 1980 Nov;65(5):1039-48. PubMed
  • Klein-Szanto AJ, Martin DH, Pine AH. Cutaneous manifestations in rats with advanced vitamin A deficiency. J Cutan Pathol. 1980 Aug;7(4):260-70. PubMed
  • Clark JN, Klein-Szanto AJ, Pine AH, Stephenson KB, Marchok AC. Reestablishment of a mucociliary epithelium in tracheal organ cultures exposed to retinyl acetate: a biochemical and morphometric study. Eur J Cell Biol. 1980 Aug;21(3):261-8. PubMed
  • Klein-Szanto AJ, Major SK, Slaga TJ. Induction of dark keratinocytes by 12-O-tetradecanoylphorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency. Carcinogenesis. 1980 May;1(5):399-406. PubMed
  • Slaga TJ, Klein-Szanto AJ, Fischer SM, Weeks CE, Nelson K, Major S. Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2251-4. PubMed
  • Klein-Szanto AJ, Nettesheim P, Topping DC, Olson AC. Quantitative analysis of disturbed cell maturation in dysplastic lesions of the respiratory tract epithelium. Carcinogenesis. 1980;1(12):1007-16. PubMed
  • Klein-Szanto AJ, Clark JN, Martin DH. Sexual differences in the distribution of epithelial alterations in vitamin A-deficient rats. Int J Vitam Nutr Res. 1980;50(1):61-9. PubMed
  • Slaga TJ, Fischer SM, Weeks CE, Klein-Szanto AJ. Multistage chemical carcinogenesis in mouse skin. Curr Probl Dermatol. 1980;10:193-218. PubMed
  • Klein-Szanto AJ, Topping DC, Heckman CA, Nettesheim P. Ultrastructural characteristics of carcinogen-induced dysplastic changes in tracheal epithelium. Am J Pathol. 1980 Jan;98(1):83-100. PubMed
  • Klein-Szanto AJ, Topping DC, Heckman CA, Nettesheim P. Ultrastructural characteristics of carcinogen-induced nondysplastic changes in tracheal epithelium. Am J Pathol. 1980 Jan;98(1):61-82. PubMed
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1970 - 1979

  • Lanfranchi H, Klein-Szanto AJ, de Rey BM, Cabrini RL. Dose-dependent volume changes in X-irradiated keratinocytes. Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Dec;36(6):659-63. PubMed
  • Klein-Szanto AJ, de Rey BM. Surface architecture of X-irradiated hair follicles. J Cutan Pathol. 1978 Aug;5(4):184-92. PubMed
  • Schroeder HE, Klein-Szanto AJ, Bánóczy J. [Leukoplakia simplex or metaplastic keratosis of the mouth mucosa?]. Zahn Mund Kieferheilkd Zentralbl. 1978;66(2):141-54. German. PubMed
  • Klein-Szanto AJ. Clear and dark basal keratinocytes in human epidermis. A stereologic study. J Cutan Pathol. 1977 Oct;4(5):275-80. PubMed
  • Klein-Szanto AJ, Schroeder HE. Architecture and density of the connective tissue papillae of the human oral mucosa. J Anat. 1977 Feb;123(Pt 1):93-109. PubMed
  • Klein-Szanto AJ. Stereologic baseline data of normal human epidermis. J Invest Dermatol. 1977 Feb;68(2):73-8. PubMed
  • Klein-Szanto AJ, De Rey BM, Cabrini RL. Volumetric modifications of X-irradiated keratinocytes. J Cutan Pathol. 1977;4(1):23-31. PubMed
  • Banoczy J, Klein-Szántõ A, Schroeder H. [Mophometric study of the mouth mucosa in leukoplakia simplex]. Morphol Igazsagugyi Orv Sz. 1977 Feb;17(1):18-25. Hungarian. PubMed
  • Klein-Szanto AJ, Andersen L, Schroeder HE. Epithelial differentiation patterns in buccal mucosa affected by lichen planus. Virchows Arch B Cell Pathol. 1976 Nov 24;22(3):245-61. PubMed
  • Klein-Szanto AJ, Bánóczy J, Schroeder HE. Metaplastic conversion of the differentiation pattern in oral epithelia affected by leukoplakia simplex. A stereologic study. Pathol Eur. 1976;11(3):189-210. PubMed
  • Simes RJ, Barros RE, Klein-Szanto AJ, Cabrini RL. Ultrastructure of an odontogenic myxoma. Oral Surg Oral Med Oral Pathol. 1975 Apr;39(4):640-6. PubMed
  • Klein-Szanto AJ, Cabrini RL, Itoiz ME, Volco HE. Letter: Enzyme variations produced in epidermis by soft x-ray collimated beams. Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Sep;26(3):285-8. PubMed
  • Itoiz ME, Frasch AC, Volco HE, Klein-Szanto AJ. Microspectrophotometric study of acid phosphatase activity in irradiated squamous epithelium. Strahlentherapie. 1974 Jun;147(6):643-8. PubMed
  • Schajowicz F, Cabrini RL, Simes RJ, Klein-Szanto AJ. Ultrastructure of chondrosarcoma. Clin Orthop Relat Res. 1974 May;(100):378-86. PubMed
  • Klein-Szanto AJ, de Rey BL, Conti CJ, Cabrini RL. Ultrastructure of irradiated nuclei. Strahlentherapie. 1974 Mar;147(3):263-70. PubMed
  • Conti CJ, Klein-Szanto AJ, Moreira JL. Effects of radiation on cultured BHK cells and their latent R particles. An electron microscope study. Arch Geschwulstforsch. 1974;43(3):254-67. PubMed
  • Klein-Szanto AJ, Conti CJ, Cartagenova RE. Ultrastructure of a vaginal myxoma of a rat. Vet Pathol. 1974;11(4):289-96. PubMed
  • Klein-Szanto AJ, Conti CJ, Mayo J. Ultramorphological features of an experimental hamster sarcoma. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 Dec 28;80(4):277-84. PubMed
  • Mayo J, Lombardo L, Klein-Szanto AJ, Conti CJ, Moreira JL. An oncogenic virus carried by hamster kidney cells. Cancer Res. 1973 Oct;33(10):2273-7. PubMed
  • Conti CJ, Klein-Szanto AJ. Nuclear multivesicular bodies in cultured hamster cells. Experientia. 1973;29(7):850-1. PubMed
  • 226: Klein-Szanto AJ, Cabrini RL. Ultrastructure of irradiated growth cartilage. J Pathol. 1973 Jan;109(1):P8. PubMed
  • De Rey BL, Klein-Szanto AJ. A histometric study of acute radiation effects on rat tail epidermis. Strahlentherapie. 1972 Jun;143(6):699-704. PubMed
  • Klein-Szanto AJ, Cabrini RL. Acute response of oxidative enzyme systems in epidermis subjected to beta-radiation. Arch Dermatol Forsch. 1972;243(3):226-31. PubMed
  • Cabrini RL, Klein-Szanto AJ, Itoiz ME. Unidirectional scanning for the microspectrophotometric investigation of enzyme reactions in squamous epithelium. Acta Histochem. 1970;36(2):399-403. PubMed
  • Cabrini RL, Itoiz ME, Mayo J, Smolko EE, Klein-Szanto AJ. Microspectrophotometric study of histoenzymic reactions in rat epidermis subjected to 0-5 Mrads of deuteron radiation. Int J Radiat Biol Relat Stud Phys Chem Med. 1970;18(5):415-21. PubMed
  • Klein-Szanto AJ, Cabrini RL. Microspectrophotometric study of oxidative enzymes in irradiated epidermis. Int J Radiat Biol Relat Stud Phys Chem Med. 1970;18(3):235-41. PubMed
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