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Publications

• Kappes DJ. Developing intestinal fortitude. Nat Immunol. 2011 Apr;12(4):281-2.
• De Keersmaecker K, Real PJ, Della Gatta G, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Cave H, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA. The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med. 2010 Nov;16(11):1321-7.
• He X, Park K, Kappes DJ. The Role of ThPOK in Control of CD4/CD8 Lineage Commitment. Annu Rev Immunol. 2010 Apr 23;28:295-320.
• Kappes DJ. Expanding roles for ThPOK in thymic development. Immunol Rev. 2010 Nov;238(1):182-94.
• Kim ST, Touma M, Takeuchi K, Sun ZY, Dave VP, Kappes DJ, Wagner G, Reinherz EL. Distinctive CD3 Heterodimeric Ectodomain Topologies Maximize Antigen-Triggered Activation of alpha beta T Cell Receptors. J Immunol. 2010 Sep;185(5):2951-9.
• Lee SY, Stadanlick J, Kappes DJ, Wiest DL. Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice. Semin Immunol. 2010 Aug;22(4):237-46.
• Engel I, Hammond K, Sullivan BA, He X, Taniuchi I, Kappes D, Kronenberg M. Co-receptor choice by V alpha 14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. J Exp Med. 2010 May;207(5):1015-29.
• He X, Park K, Kappes DJ. The Role of ThPOK in Control of CD4/CD8 Lineage Commitment. In: Paul WE, editor. Annual Review of Immunology, Vol 28. Palo Alto: Annual Reviews; 2010. p. 295-320.
• Park K, He X, Lee HO, Hua XA, Li Y, Wiest D, Kappes DJ. TCR-mediated ThPOK induction promotes development of mature (CD24-) gamma delta thymocytes. EMBO J. 2010 Jul;29(14):2329-41.
• Lee SY, Stadanlick J, Kappes DJ, Wiest DL. Towards a molecular understanding of the differential signals regulating or alpha beta/gamma delta T lineage choice. Semin Immunol. 2010 Aug;22(4):237-46.
• Lauritsen JP, Wong GW, Lee SY, Lefebvre JM, Ciofani M, Rhodes M, Kappes DJ, Zuniga-Pflucker JC, Wiest DL. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. Immunity. 2009 Oct 16;31(4):565-75.
• He X, Park K, Wang H, Zhang Y, Hua X, Li Y, Kappes DJ. CD4-CD8 Lineage Commitment Is Regulated by a Silencer Element at the ThPOK Transcription-Factor Locus. Immunity. 2008 Mar;28(3):346-58.
• Kappes D, Hagman J. Lymphocyte development - Regulation of B and T lymphoid cell development. Curr Opin Immunol. 2007 Apr;19(2):113-5.
• Kappes DJ. CD4 and CD8: Hogging All the Lck. Immunity. 2007 Nov 26;27(5):691-3.
• He X, Kappes DJ. CD4/CD8 lineage commitment: light at the end of the tunnel?. Curr Opin Immunol. 2006 Apr;18(2):135-42.
• Kappes DJ, He X. Role of the transcription factor Th-POK in CD4:CD8 lineage commitment. Immunol Rev. 2006 Feb;209:237-52.
• Lauritsen JP, Haks MC, Lefebvre JM, Kappes DJ, Wiest DL. Recent insights into the signals that control alphabeta/gammadelta-lineage fate. Immunol Rev. 2006 Feb;209:176-90.
• Kappes DJ, He X, He X. Role of the transcription factor Th-POK in CD4:CD8 lineage commitment. Immunol Rev. 2006 Feb 209(2):237-52.
• Sulis ML, Palomero T, Real PJ, Barnes KC, Aplan P, Copeland N, Utpal D, Gounari F, Grosveld G, Kappes DJ, Kee B, Kelliher M, Lenz J, Richardson C, Ferrando A, Ferrando A. Identification of oncogenic pathways of T-Acute lymphoblastic leukemia (T-ALL) through gene expression profiling of mouse tumor models. Blood. 2006 Nov;108(11):633A-633A.
• Haks MC, Lefebvre JM, Lauritsen JP, Carleton M, Rhodes M, Miyazaki T, Kappes DJ, Wiest DL. Attenuation of gdTCR signaling efficiently diverts thymocytes to the ab lineage. Immunity. 2005;22(5):595-606.
• He X, Dave VP, Zhang Y, Hua X, Nicolas E, Xu WH, Roe BA, Kappes DJ. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature. 2005 Feb 24;433(7028):826-33.
• Kappes DJ, He X. CD4-CD8 lineage commitment: an inside view. Nat Immunol. 2005 Aug;6(8):761-6.
• Hayes SM, Laky K, El-Khoury D, Kappes DJ, Fowlkes BJ, Love PE. Activation-induced modification in the CD3 complex of the T cell receptor. J Exp Med. 2002;96:1355-61.
• Malstrom S, Tili E, Kappes D, Ceci JD, Tsichlis PN. Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. Proc Natl Acad Sci USA. 2001;98:14967-72.
• Delgado P, Fernandez E, Dave V, Kappes D, Alarcon B. CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Nature. 2000;406(6794):426-30.
• Keefe R, Dave V, Allman D, Wiest D, Kappes DJ. Regulation of lineage commitment distinct from positive selection. Science. 1999;286(5442):1149-53.
• Dave VP, Allman D, Keefe R, Hardy RR, Kappes DJ. HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc Natl Acad Sci USA. 1998;95(14):8187-92.
• Dave VP, Cao Z, Browne C, Alarcon B, Fernandez-Miguel G, Lafaille J, de la Hera A, Tonegawa S, Kappes DJ. CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. EMBO J. 1997;16(6):1360-70.